Home LiteratureArticle Details
PMID: 3972412 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fragile sites and structural rearrangements in cancer.

Human genetics ·Vol. 69 ·No. 2 ·1985-00-00 ·Pages 112-6

De Braekeleer M, Smith B, Lin CC

Abstract

We retracted information from a computerized databank which contains the cytogenetic findings of 17,000 patients with leukemia and lymphoma. Cytogenetic data from patients with solid tumors were compiled from Dr. Mitelman's catalogue on "Chromosome aberrations in cancer". We compared the observed distribution of breaks in chromosome bands involved in structural rearrangements with the random distribution of breaks generated by Monte Carlo simulation and showed that a majority but not all of the bands known to contain a fragile site are involved in structural aberrations in cancer and that some of them are associated with specific chromosome structural changes in specific types of cancer.

MeSH Terms
Chromosome Aberrations Chromosome Banding Chromosome Deletion Chromosome Fragile Sites Chromosome Fragility Humans Leukemia/genetics Lymphoma/genetics Monte Carlo Method Neoplasms/genetics Translocation, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
De Braekeleer M
Smith B
Lin C C
References (34)
34 references, click to expand
  1. Coincidence between fragile site expression and interstitial deletion of chromosome 11 in a case of myelofibrosis.
    Hum Genet. 1983;63(3):299-301 PMID: 6852829
  2. A new familial "fragile site" on chromosome 16 (q23-24). Cytogenetic and clinical considerations.
    Hum Genet. 1983;64(3):273-6 PMID: 6604013
  3. Heritable fragile sites in cancer.
    Nature. 1984 Apr 12-18;308(5960):607-8 PMID: 6709072
  4. Karyotype peculiarities of malignant lymphomas.
    Hum Genet. 1977 Mar 14;35(3):269-79 PMID: 321328
  5. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association.
    Blood. 1983 May;61(5):994-8 PMID: 6831056
  6. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.
    Cytogenet Cell Genet. 1981;31(1):5-23 PMID: 7297128
  7. Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma.
    Hum Genet. 1982;60(3):291-3 PMID: 7106763
  8. Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.
    Ann Genet. 1973 Jun;16(2):109-12 PMID: 4125056
  9. Heritable fragile sites and lymphocyte culture medium containing BrdU.
    Am J Hum Genet. 1980 Jul;32(4):628-9 PMID: 7395874
  10. Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.
    Science. 1982 Sep 3;217(4563):939-41 PMID: 7112106
  11. A new chromosome anomaly in acute lymphoblastic leukemia (ALL).
    Hum Genet. 1979 Jan 25;46(2):173-80 PMID: 283972
  12. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.
    N Engl J Med. 1983 Sep 15;309(11):630-6 PMID: 6577285
  13. Epstein-Barr-virus-induced lymphoproliferative disorder converting to fatal Burkitt-like lymphoma in a boy with interferon-inducible chromosomal defect.
    Lancet. 1980 Nov 8;2(8202):997-1002 PMID: 6159514
  14. A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC).
    Cancer Genet Cytogenet. 1982 Jun;6(2):119-34 PMID: 6286098
  15. Second International Workshop on Chromosomes in Leukemia.
    Cancer Res. 1980 Dec;40(12):4826-7 PMID: 6108161
  16. A new inducible fragile site on chromosome 3(p14.2) in human lymphocytes.
    Hum Genet. 1983;63(3):297-8 PMID: 6852828
  17. Hereditary renal-cell carcinoma associated with a chromosomal translocation.
    N Engl J Med. 1979 Sep 13;301(11):592-5 PMID: 470981
  18. The chromosomal basis of human neoplasia.
    Science. 1983 Jul 15;221(4607):227-36 PMID: 6336310
  19. Genetic mechanisms in cancer predisposition: report of a cancer family.
    Cancer. 1979 Feb;43(2):679-89 PMID: 217526
  20. Translocation (9;11)(p21;q23) in three cases of acute monoblastic leukemia.
    Cancer Genet Cytogenet. 1982 Feb;5(2):95-105 PMID: 6950808
  21. Acute myeloblastic leukemia (AML) with t(6;9) (p23;q34): a specific subgroup of AML?
    Cancer Genet Cytogenet. 1983 Oct;10(2):139-42 PMID: 6577939
  22. Constitutional chromosomal breakage.
    Hum Genet. 1976 Oct 28;34(2):125-36 PMID: 1033912
  23. A possible subgroup of ALL with 9p-.
    Cancer Genet Cytogenet. 1983 Aug;9(4):383-5 PMID: 6575861
  24. Fragile sites and predisposition to leukemia and lymphoma.
    Cancer Genet Cytogenet. 1984 May;12(1):85-8 PMID: 6713362
  25. Fragile sites and cancer breakpoints.
    Cancer Genet Cytogenet. 1984 Jun;12(2):179-81 PMID: 6722758
  26. [Comparative cytogenetic study of 7 types of mammary cancer].
    Ann Genet. 1977 Sep;20(3):171-7 PMID: 304700
  27. Catalogue of chromosome aberrations in cancer.
    Cytogenet Cell Genet. 1983;36(1-2):1-515 PMID: 6627995
  28. Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage.
    Science. 1983 Apr 1;220(4592):69-70 PMID: 6828880
  29. Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23.
    Am J Hum Genet. 1983 May;35(3):432-7 PMID: 6859039
  30. Chromosomal patterns in a benign human neoplasm, the mixed salivary gland tumour.
    Hereditas. 1982;96(1):141-8 PMID: 6282787
  31. Chromosome 17 has a real fragile site at p12.
    Hum Genet. 1982;61(2):177-9 PMID: 7129447
  32. The fragile X chromosome.
    Int Rev Cytol. 1983;81:107-43 PMID: 6347931
  33. Demonstration of a heritable fragile site in human chromosome 16 with distamycin A.
    Cytogenet Cell Genet. 1980;28(1-2):87-94 PMID: 7449440
  34. Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.
    Am J Hum Genet. 1980 Jul;32(4):542-8 PMID: 7395866
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00293279
Published
1985-00-00
Pages
112-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00293279 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2