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PMID: 4044042 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Lack of correlation between known virulence properties of Aeromonas hydrophila and enteropathogenicity for humans.

Infection and immunity ·Vol. 50 ·No. 1 ·1985-10-00 ·Pages 62-5

Morgan DR, Johnson PC, DuPont HL, Satterwhite TK, Wood LV

Abstract

Five strains of Aeromonas hydrophila were selected for use in volunteer challenge trials. All five strains produced cytotoxin, hemolysin enterotoxin, lysine decarboxylase, acetylmethylcarbinol, and DNase. Two strains hydrolyzed esculin. All strains produced purulent hemorrhagic fluid accumulation in rabbit ileal loops, but failed to induce keratoconjunctivitis in guinea pigs. None of the strains produced mannose-resistant hemagglutinins. In challenge studies, diarrhea was demonstrated in only 2 of 57 human volunteers with doses ranging from 10(4) to 10(10) CFU. One person experienced mild diarrhea with 10(9) CFU of strain 6Y. A second person developed moderate diarrhea with 10(7) CFU of strain 3647. At higher doses, no diarrhea was seen in any of the volunteers. The other three strains (B158, SSU, 3284) failed to cause diarrhea and were not recovered from stools of volunteers. Additional virulence properties of A. hydrophila need to be sought before enteropathogenicity for humans can be established.

MeSH Terms
Aeromonas/pathogenicity Animals Biological Assay Cytotoxins/biosynthesis Diarrhea/microbiology Enterotoxins/biosynthesis Guinea Pigs Hemagglutinins/analysis Hemolysis Humans Ileum/microbiology Keratoconjunctivitis/microbiology Rabbits
Chemicals
Cytotoxins Enterotoxins Hemagglutinins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Morgan D R
Johnson P C
DuPont H L
Satterwhite T K
Wood L V
References (33)
33 references, click to expand
  1. Differences in the response of rabbit small intestine to heat-labile and heat-stable enterotoxins of Escherichia coli.
    Infect Immun. 1973 Jun;7(6):873-80 PMID: 4577415
  2. Immunological cross-reactivity of enterotoxins of Aeromonas hydrophila and cholera toxin.
    Clin Exp Immunol. 1982 Jan;47(1):34-42 PMID: 7047024
  3. Isolation of Aeromonas from faeces.
    Lancet. 1983 Feb 12;1(8320):351 PMID: 6130348
  4. Hemagglutination patterns of Aeromonas spp. in relation to biotype and source.
    J Clin Microbiol. 1984 Jan;19(1):39-43 PMID: 6690466
  5. The genus aeromonas in human bacteriology; report of 30 cases and review of the literature.
    N Engl J Med. 1968 Feb 1;278(5):245-9 PMID: 5635458
  6. Enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides: prevalence among individuals with and without diarrhea in Thailand.
    Infect Immun. 1982 Feb;35(2):666-73 PMID: 7056580
  7. Enzymatic characterization of Aeromonas hydrophila complex by the API ZYM system.
    J Clin Microbiol. 1982 Oct;16(4):692-6 PMID: 6818246
  8. Enterotoxin production in relation to taxonomic grouping and source of isolation of Aeromonas species.
    J Clin Microbiol. 1984 Feb;19(2):175-80 PMID: 6699147
  9. Enterobacteriaceae and Aeromonas hydrophila in Minnesota frogs and tadpoles (Rana pipiens).
    Appl Environ Microbiol. 1983 Dec;46(6):1423-5 PMID: 6607034
  10. Pathogenesis of Escherichia coli diarrhea.
    N Engl J Med. 1971 Jul 1;285(1):1-9 PMID: 4996788
  11. Hemagglutination properties and adherence ability of Aeromonas hydrophila.
    Infect Immun. 1980 Mar;27(3):938-46 PMID: 6103874
  12. Septicemia due to Aeromonas hydrophila: clinical and immunologic aspects.
    J Infect Dis. 1973 Mar;127(3):284-90 PMID: 4688925
  13. Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive.
    Lancet. 1978 May 27;1(8074):1119-22 PMID: 77415
  14. Comparison of methods to detect Escherichia coli heat-labile enterotoxin in stool and cell-free culture supernatants.
    J Clin Microbiol. 1983 Oct;18(4):798-802 PMID: 6355159
  15. Aeromonas hydrophila in acute diarrheal disease: detection of enterotoxin and biotyping of strains.
    J Clin Microbiol. 1977 Aug;6(2):96-100 PMID: 893660
  16. Prospective study of enteropathogens in children with diarrhea in Houston and Mexico.
    J Pediatr. 1978 Sep;93(3):383-8 PMID: 211215
  17. Travelers' diarrhea among American Peace Corps volunteers in rural Thailand.
    J Infect Dis. 1981 Jun;143(6):767-71 PMID: 7019355
  18. Bicozamycin, a poorly absorbable antibiotic, effectively treats travelers' diarrhea.
    Ann Intern Med. 1983 Jan;98(1):20-5 PMID: 6336641
  19. Aeromonas hydrophila and Plesiomonas shigelloides as causes of intestinal infections.
    Rev Infect Dis. 1984 Sep-Oct;6(5):633-9 PMID: 6390638
  20. Diarrhea caused by Shigella, rotavirus, and Giardia in day-care centers: prospective study.
    J Pediatr. 1981 Jul;99(1):51-6 PMID: 6265616
  21. Association of Aeromonas sobria with human infection.
    J Clin Microbiol. 1981 Apr;13(4):769-77 PMID: 6112237
  22. Hemagglutination typing of Escherichia coli: definition of seven hemagglutination types.
    J Clin Microbiol. 1980 Aug;12(2):235-42 PMID: 7014607
  23. Experimental shigella keratoconjunctivitis; a preliminary report.
    Acta Microbiol Acad Sci Hung. 1955;2(3):293-6 PMID: 14387586
  24. Dysentery-like syndrome associated with Aeromonas hydrophila.
    Br Med J. 1980 Oct 11;281(6246):976 PMID: 7427550
  25. Evaluation of differential and selective media for isolation of Aeromonas and Plesiomonas spp. from human feces.
    J Clin Microbiol. 1983 Jan;17(1):16-21 PMID: 6826700
  26. Fatal Aeromonas hydrophila infection of the skin.
    South Med J. 1978 Jun;71(6):739-41 PMID: 663710
  27. The microbiology of childhood gastroenteritis: Aeromonas species and other infective agents.
    J Infect Dis. 1983 Jul;148(1):68-74 PMID: 6886488
  28. Cholera-like illness due to Aeromonas sobria.
    J Infect Dis. 1982 Feb;145(2):248-54 PMID: 7054327
  29. Human aeromonas infections: a review of the literature and a case report of endocarditis.
    Medicine (Baltimore). 1978 May;57(3):267-77 PMID: 347223
  30. A taxonomic study of the Aeromonas hydrophila-Aeromonas punctata group.
    J Gen Microbiol. 1976 May;94(1):11-22 PMID: 932684
  31. Clinical involvement of Aeromonas hydrophila.
    Can Med Assoc J. 1979 Apr 21;120(8):942-6 PMID: 373876
  32. Treatment of travelers' diarrhea with trimethoprim/sulfamethoxazole and with trimethoprim alone.
    N Engl J Med. 1982 Sep 30;307(14):841-4 PMID: 7050714
  33. Aeromonas hydrophila: ecology and toxigenicity of isolates from an estuary.
    J Appl Bacteriol. 1981 Apr;50(2):359-77 PMID: 7251516
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.50.1.62-65.1985
Published
1985-10-00
Pages
62-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC262135
Subset
IM
Grants
NCRR NIH HHS · RR00350 · United States
External Links
PubMed source DOI: 10.1128/iai.50.1.62-65.1985 PMC Full Text View journal details
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