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PMID: 411874 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of cell-mediated responsiveness to an AKR tumor-associated antigen: mapping of the locus involved to the I region of the H-2 complex.

The Journal of experimental medicine ·Vol. 146 ·No. 5 ·1977-11-01 ·Pages 1367-79

Meruelo D, Deak B, McDevitt HO

Abstract

The role of H-2-linked genes in controlling resistance to murine leukemia viruses has been studied by measuring the cell-mediated immune response of F1 hybrid mice (between AKR and various C3H and C57BL/10 derived, H-2 congenic strains) to an AKR tumor cell line, BW5147. The studies have shown that the ability to generate a primary or secondary cell-mediated response to an AKR tumor cell antigenic determinant is under H-2 linked control. The locus determining CML responsiveness maps in the I-J subregion. Nonresponsiveness is associated with the H-2q/k and H-2b/k hybrid genotypes, whereas responsiveness is associated with the H-2k/k homozygous genotype. Nonresponsiveness may result from (a) dominant suppression; (b) recessive responsiveness; or (c) an alternate mechanism not yet understood. This type of control may be one of several H-2-associated mechanisms of defense against virus-induced neoplasms.

MeSH Terms
Animals Antigens, Neoplasm Cell Line Chromosome Mapping Cytotoxicity, Immunologic Genes, MHC Class II Genetic Linkage Histocompatibility Hybridization, Genetic Immunity, Cellular Leukemia, Experimental/genetics,immunology Mice Mice, Inbred AKR Mice, Inbred Strains Species Specificity
Chemicals
Antigens, Neoplasm
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Meruelo D
Deak B
McDevitt H O
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20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.5.1367
Published
1977-11-01
Pages
1367-79
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180965
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.5.1367 PMC Full Text View journal details
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