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PMID: 4632133 Published · ppublish English Journal Article

Effect of anti-cord factor antibody on experimental tuberculosis in mice.

Infection and immunity ·Vol. 7 ·No. 1 ·1973-01-00 ·Pages 14-21

Kato M

Abstract

Either active immunization with trehalose-6, 6'-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis. This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cord factor during the course of living virulent infection with tubercle bacilli. The protective effect of active immunization with cord factor-methylated bovine serum albumin complex and of anti-cord factor serum was found to be specific for the tuberculous infection among a number of experimental infections in mice with a variety of cytopathogenic microorganisms tested.

MeSH Terms
Animals Antibodies Brucella abortus/immunology Immune Sera Immunity, Maternally-Acquired Immunization Immunization, Passive Listeria monocytogenes/immunology Lung/microbiology Mice Mycobacterium tuberculosis/immunology,isolation & purification Mycolic Acids Salmonella enteritidis/immunology Salmonella typhimurium/immunology Serum Albumin, Bovine Spleen/microbiology Tuberculosis/immunology
Chemicals
Antibodies Immune Sera Mycolic Acids Serum Albumin, Bovine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kato M
References (16)
16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.7.1.14-21.1973
Published
1973-01-00
Pages
14-21
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422632
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.7.1.14-21.1973 PMC Full Text View journal details
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