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PMID: 4670441 Published · ppublish English Comparative Study Journal Article

Inhibition of peptidoglycan synthesis by the antibiotic diumycin A.

Antimicrobial agents and chemotherapy ·Vol. 2 ·No. 6 ·1972-12-00 ·Pages 485-91

Lugtenberg EJ, Hellings JA, van de Berg GJ

Abstract

Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects,metabolism Peptidoglycan/biosynthesis Phospholipids/pharmacology Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Peptidoglycan Phospholipids Vancomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lugtenberg E J
Hellings J A
van de Berg G J
References (27)
27 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.2.6.485
Published
1972-12-00
Pages
485-91
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444343
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.2.6.485 PMC Full Text View journal details
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