Home LiteratureArticle Details
PMID: 481427 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Action of staphylococcal alpha-toxin on membranes: some recent advances.

Molecular and cellular biochemistry ·Vol. 23 ·No. 3 ·1979-02-09 ·Pages 143-52

Harshman S

Abstract

Recent developments in the area of Staphylococcal alpha-toxin studies are presented which modify the concepts previously held with respect to both biological and physical properties of alpha-toxin. New data concerning the nature of the binding site for alpha-toxin on rabbit erythrocyte membranes and a model to explain the various observed complexes of alpha-toxin and membrane receptor are discussed. Finally, evidence suggesting that Staphylococcal alpha-toxin is a potent demyelinating agent is presented.

MeSH Terms
Animals Bacterial Toxins/metabolism,pharmacology Binding Sites Erythrocyte Membrane/drug effects,metabolism Erythrocytes/drug effects Hemolysin Proteins Hemolysis/drug effects Humans In Vitro Techniques Iodine Radioisotopes Mice Models, Biological Myelin Sheath/drug effects Neurotoxins/pharmacology Rabbits Staphylococcus
Chemicals
Bacterial Toxins Hemolysin Proteins Iodine Radioisotopes Neurotoxins staphylococcal alpha-toxin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Harshman S
References (36)
36 references, click to expand
  1. ACTION OF STAPHYLOCOCCAL TOXIN ON HUMAN PLATELETS.
    J Infect Dis. 1964 Dec;114:488-502 PMID: 14233140
  2. EFFECT OF STAPHYLOCOCCAL AND OTHER BACTERIAL TOXINS ON PLATELETS IN VITRO.
    J Pathol Bacteriol. 1965 Jan;89:209-23 PMID: 14263463
  3. Lipid monolayers: influence of lipid film and urea on the surface activity of staphylococcal alpha-toxin.
    Lipids. 1971 Aug;6(8):546-53 PMID: 5094765
  4. Disruption of wall-less bacteria by streptococcal and staphylococcal toxins.
    J Bacteriol. 1966 May;91(5):1677-80 PMID: 5327903
  5. Purification and properties of two forms of staphylococcal toxin.
    Biochemistry. 1973 Jul 3;12(14):2672-7 PMID: 4197123
  6. HEMOLYSIS OF RABBIT ERYTHROCYTES BY PURIFIED STAPHYLOCOCCAL ALPHA-TOXIN. III. POTASSIUM RELEASE.
    J Bacteriol. 1964 Jan;87:145-9 PMID: 14102847
  7. Studies on extracellular proteins from Staphylococcus aureus. IV. Separation of alpha-toxin by isoelectric focusing.
    Biochim Biophys Acta. 1968 Oct 21;168(2):228-42 PMID: 5748673
  8. Staphylococcal sphingomyelinase (beta-hemolysin).
    Ann N Y Acad Sci. 1974 Jul 31;236(0):292-306 PMID: 4371058
  9. Purification and some properties of staphylococcal alpha-toxin.
    Jpn J Exp Med. 1974 Apr;44(2):165-78 PMID: 4546168
  10. Specific binding of staphylococcal alpha-toxin to isolated rabbit vagus nerves in vitro.
    Infect Immun. 1978 Sep;21(3):1024-6 PMID: 711327
  11. Heat stability and species range of purified staphylococcal alpha-toxin.
    J Bacteriol. 1966 May;91(5):1686-92 PMID: 5937231
  12. The binding of staphylococcal 125I-alpha-toxin (B) to erythrocytes.
    J Biol Chem. 1973 Aug 10;248(15):5545-6 PMID: 4806341
  13. Physical and chemical studies on staphylococcal -toxins A and B .
    Biochemistry. 1973 Jul 3;12(14):2677-83 PMID: 4711471
  14. Studies on the binding of staphylococcal 125I-labeled alpha-toxin to rabbit erythrocytes.
    Biochemistry. 1976 Jun 1;15(11):2348-55 PMID: 1276142
  15. Ultracentrifugal analysis of staphylococcal alpha toxin.
    J Bacteriol. 1971 Apr;106(1):138-42 PMID: 5551634
  16. Some effects of staphylococcal alpha-toxin on isolated mammalian smooth muscle preparations.
    Br J Pharmacol Chemother. 1965 Dec;25(3):781-9 PMID: 4380601
  17. Staphylococcal alpha-toxin-induced contraction of isolated arterial smooth muscle.
    Am J Physiol. 1966 Feb;210(2):360-4 PMID: 4379087
  18. Production, purification, and composition of staphylococcal alpha toxin.
    J Bacteriol. 1966 Dec;92(6):1655-62 PMID: 4959717
  19. Effects of staphylococcus alpha-toxin and streptolysin S on the oxidation of succinate by ascites tumour cells.
    J Med Microbiol. 1969 Nov 4;2(4):495-505 PMID: 5404804
  20. Isolation and composition of staphylococcal alpha toxin.
    J Gen Microbiol. 1963 Mar;30:455-68 PMID: 13967637
  21. Ultrastructure of membrane lesions in immune lysis, osmotic lysis and drug-induced lysis.
    Fed Proc. 1974 Oct;33(10):2116-24 PMID: 4607618
  22. Effects of staphylococcal alpha-, beta-, delta-, and gamma-hemolysins on human diploid fibroblasts and HeLa cells: evaluation of a new quantitative as say for measuring cell damage.
    Infect Immun. 1973 Dec;8(6):938-46 PMID: 4784889
  23. Effects of staphylococcal -toxin on the structure of erythrocyte membranes: a biochemical and freeze-etching study.
    J Gen Microbiol. 1973 Apr;75(2):321-32 PMID: 4706973
  24. Lipid monolayers. Interactions with staphylococcal alpha-toxin.
    Biochim Biophys Acta. 1971 Mar 9;233(1):7-16 PMID: 4325423
  25. Inhibition of Na+-K-dependent ATPase in vivo by staphylococcal alpha-hemolysin.
    Biochem Pharmacol. 1971 Oct;20(10):2916-7 PMID: 4255931
  26. The site of action of the Staphylococcus alpha toxin.
    J Exp Med. 1961 Jan 1;113:67-82 PMID: 13776153
  27. Purification of staphylococcal alpha-toxin by adsorption chromatography on glass.
    Infect Immun. 1976 Mar;13(3):982-6 PMID: 1270140
  28. LYSIS OF PLEUROPNEUMONIA-LIKE ORGANISMS BY STAPHYLOCOCCAL AND STREPTOCOCCAL TOXINS.
    Science. 1965 May 28;148(3674):1229-31 PMID: 14280003
  29. Physical states of staphylococcal alpha-toxin.
    J Bacteriol. 1967 Oct;94(4):1170-7 PMID: 4963777
  30. HEMOLYSIS OF RABBIT ERYTHROCYTES BY PURIFIED STAPHYLOCOCCAL ALPHA-TOXIN. II. EFFECTS OF INHIBITORS ON THE HEMOLYTIC SEQUENCE.
    J Bacteriol. 1964 Jan;87:136-44 PMID: 14102846
  31. Multiple forms of staphylococcal alpha-toxin.
    J Med Microbiol. 1972 Feb;5(1):113-22 PMID: 4623346
  32. Cytolytic toxins of bacterial origin. The nature and properties of cytolytic proteins are discussed with emphasis on staphylococcal alpha-toxin.
    Science. 1968 Feb 23;159(3817):847-51 PMID: 4295145
  33. Interaction of staphylococcal alpha-toxin with artificial and natural membranes.
    J Bacteriol. 1968 Mar;95(3):1153-68 PMID: 5643052
  34. Studies of the Biologic Activity of Purified Staphylococcal Alpha-Toxin: II. The Effect of Alpha-Toxin on Ehrlich Ascites Carcinoma Cells.
    Yale J Biol Med. 1963 Apr;35(5):382-9 PMID: 21434289
  35. Mode of action of the alpha toxin of Staphylococcus aureus.
    Can J Microbiol. 1970 Jan;16(1):47-50 PMID: 5461221
  36. Staphylococcal alpha-toxin: effects on artificial lipid spherules.
    Science. 1966 Nov 11;154(3750):772-4 PMID: 5919441
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00219453
Published
1979-02-09
Pages
143-52
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00219453 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2