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PMID: 5273452 Published · ppublish English Journal Article

Genetic control of the immune response of guinea pigs to limiting doses of bovine serum albumin: relationship to the poly-L-lysine gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 4 ·1970-08-00 ·Pages 1267-74

Green I, Inman JK, Benacerraf B

Abstract

The response of strain 2 guinea pigs to limiting doses of bovine serum albumin is under dominant genetic control linked with the poly-L-lysine gene. Inbred strains 2 and 13 guinea pigs make similar antibody responses to 10 mug bovine serum albumin, whereas strain 2 but not strain 13 animals produce significant amounts of antibodies in response to 0.1 mug. The relationship between the presence of the poly-L-lysine gene and the ability to respond to limiting doses of bovine serum albumin has also been investigated in random-bred Hartley strain guinea pigs.

MeSH Terms
Animals Antigen-Antibody Reactions Crosses, Genetic Genes, Dominant Guinea Pigs/immunology Immunization Insulin Iodine Isotopes Lysine Serum Albumin, Bovine Species Specificity Tritium
Chemicals
Insulin Iodine Isotopes Tritium Serum Albumin, Bovine Lysine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Green I
Inman J K
Benacerraf B
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.66.4.1267
Published
1970-08-00
Pages
1267-74
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC335815
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.66.4.1267 PMC Full Text View journal details
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