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PMID: 528049 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Production of hydroxyl radical by human alveolar macrophages.

Infection and immunity ·Vol. 26 ·No. 3 ·1979-12-00 ·Pages 1088-92

Hoidal JR, Beall GD, Repine JE

Abstract

Stimulated human alveolar macrophages were demonstrated to oxidize B-methyl proprionaldehyde (methional) or 2-keto-4-thiomethylbutyric acid to ethylene (C2H4). Agents which are believed to scavenge the hydroxyl radical (.OH), sodium benzoate, and mannitol, as well as scavengers of superoxide anion (O2-) or hydrogen peroxide, decreased C2H4 production, implicaing .OH as the oxidizing radical. Differences in C2H4 rpoduction, as well as oxygen uptake and O2- release between human alveolar macrophages and polymorphonuclear leukocytes, were also documented.

MeSH Terms
Aldehydes/metabolism Butyrates/metabolism Catalase/pharmacology Ethylenes/metabolism Free Radicals/metabolism Humans Hydroxides/metabolism Keto Acids/metabolism Macrophages/metabolism Neutrophils/metabolism Oxygen/metabolism Oxygen Consumption Pulmonary Alveoli/cytology Sulfhydryl Compounds/metabolism Superoxide Dismutase/pharmacology Zymosan/pharmacology
Chemicals
Aldehydes Butyrates Ethylenes Free Radicals Hydroxides Keto Acids Sulfhydryl Compounds methional Zymosan Catalase Superoxide Dismutase Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hoidal J R
Beall G D
Repine J E
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28 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.26.3.1088-1092.1979
Published
1979-12-00
Pages
1088-92
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414731
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.26.3.1088-1092.1979 PMC Full Text View journal details
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