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PMID: 5343431 Published · ppublish English Journal Article

Species specificity of leukocytic pyrogens.

The Journal of experimental medicine ·Vol. 130 ·No. 4 ·1969-10-01 ·Pages 707-21

Bornstein DL, Woods JW

Abstract

Polymorphonuclear neutrophilic leukocytes of the dog, cat, and goat release leukocytic pyrogen under the same conditions as the heterophile polymorphonuclear leukocytes of the rabbit. The characteristics of the febrile response to an intravenous injection of homologous leukocytic pyrogen in all four species are very similar: a brisk monophasic fever reaching a peak between 30 and 50 min with smooth defervescence to the baseline by 3 hr. Shivering, which is not obvious in the rabbit, is noted in the dog, cat, and goat during the first 30 min. Quantitative differences in response reveal the cat to be the most sensitive of of these species to homologous leukocytic pyrogen, followed by the rabbit, dog, and goat. The response to heterologous pyrogen is in most cases markedly diminished compared to that after equal doses of homologous protein, suggesting the operation of species specificity, although canine and feline pyrogen behaved very similarly in all tests. Species specificity of leukocytic pyrogen is probably related to amino acid substitutions in different species of a common mammalian protein effector molecule.

MeSH Terms
Animals Cats Dogs Fever/chemically induced Glycogen Goats Leukocytes/metabolism Neutrophils/metabolism Peritonitis/chemically induced Pyrogens/biosynthesis Rabbits Species Specificity
Chemicals
Pyrogens Glycogen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bornstein D L
Woods J W
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29 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.130.4.707
Published
1969-10-01
Pages
707-21
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138720
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.130.4.707 PMC Full Text View journal details
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