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PMID: 6093113 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 21 ·1984-11-00 ·Pages 6696-700

Schmidt M, Glöggler K, Wirth T, Horak I

Abstract

Two endogenous retroviral long terminal repeats (LTRs) were sequenced and compared to LTR-IS (a family of insertion-element-like sequences with structural features of solitary retroviral LTRs) and to Moloney murine leukemia virus DNA. The sequence comparisons revealed that the major difference between these two endogenous LTRs is a 190-base-pair segment which is also present in LTR-IS elements. Hybridization analysis of DNAs from several mouse species using specific probes shows linkage of the 190-base-pair segment to a LTR-IS specific fragment. It is concluded that the major class of endogenous LTRs has been generated by recombination between exogenous retroviral LTRs and LTR-IS sequences.

MeSH Terms
Animals Base Sequence DNA/genetics DNA Transposable Elements DNA, Recombinant DNA, Viral/genetics Mice/genetics Moloney murine leukemia virus/genetics Nucleic Acid Hybridization Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroviridae/genetics
Chemicals
DNA Transposable Elements DNA, Recombinant DNA, Viral DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schmidt M
Glöggler K
Wirth T
Horak I
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21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.21.6696
Published
1984-11-00
Pages
6696-700
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391997
Subset
IM
Databases
GENBANK
K02892
External Links
PubMed source DOI: 10.1073/pnas.81.21.6696 PMC Full Text View journal details
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