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PMID: 6304707 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 11 ·1983-06-00 ·Pages 3327-30

Wirth T, Glöggler K, Baumruker T, Schmidt M, Horak I

Abstract

Screening of a 129/J mouse genomic library under nonstringent hybridization conditions with a xenotropic virus-like long terminal repeat (LTR) probe revealed a family of sequences resembling insertion elements (IS) with structural features of solitary retroviral LTRs; these are called LTR-IS. They are interspersed among variable flanking regions of mouse DNA and lack any viral structural genes. LTR-IS elements start and end with 11-base-pair inverted repeats and contain signals implicated in RNA polymerase II transcriptional regulation: C-C-A-A-T, T-A-T-A-A-A, and A-A-T-A-A-A. The members of the family are homologous, but not identical, approximately equal to 500-base-pair-long elements with 4-base-pair target-site duplications on both sites of the element. There are 500 LTR-IS per mouse haploid genome.

MeSH Terms
Bacteriophage lambda/genetics Base Sequence Cloning, Molecular DNA/genetics DNA Restriction Enzymes DNA, Recombinant/analysis Genes Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Retroviridae/genetics
Chemicals
DNA, Recombinant DNA DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wirth T
Glöggler K
Baumruker T
Schmidt M
Horak I
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49 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.11.3327
Published
1983-06-00
Pages
3327-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC394035
Subset
IM
Databases
GENBANK
J00636, J00637, J00638, J00639
External Links
PubMed source DOI: 10.1073/pnas.80.11.3327 PMC Full Text View journal details
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