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PMID: 6461857 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of endogenous retroviral glycoprotein 70 by antigen-activated cytotoxic and suppressor T lymphocytes of nice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 4 ·1982-02-00 ·Pages 1250-3

Klenner D, Horak I, Schimpl A, Wecker E

Abstract

Concanavalin A-stimulated murine spleen cells and antigen-stimulated B lymphocytes of normal mice express an antigen that reacts with goat antiserum against glycoprotein (gp) 70. Structural analysis of this antigen characterizes it as endogenous viral gp70 that is most likely of xenotropic origin. Activated nonspecific T suppressor cells and cytotoxic T lymphocytes express endogenous viral gp70, whereas nonactivated mouse T or B lymphocytes do not. The presence of endogenous retroviral gp70 is thus a novel marker for activated mouse lymphocytes in general.

MeSH Terms
Animals B-Lymphocytes/analysis Cytotoxicity, Immunologic Glycoproteins/analysis Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred DBA Retroviridae/analysis T-Lymphocytes/analysis,immunology T-Lymphocytes, Regulatory/analysis Viral Envelope Proteins Viral Proteins/analysis
Chemicals
Glycoproteins Viral Envelope Proteins Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Klenner D
Horak I
Schimpl A
Wecker E
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37 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.4.1250
Published
1982-02-00
Pages
1250-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345939
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.79.4.1250 PMC Full Text View journal details
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