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PMID: 6170718
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XII. Fine specificity of anti-idiotypic suppressor T cells (Ts2).
Abstract
The fine specificity of anti-idiotypic, effector-phase suppressor T cells (Ts2) induced by the intravenous injection of syngeneic spleen cells covalently coupled with the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten was studied in an in vitro plaque-forming cell system. By comparing the ability of these suppressor cells to bind monoclonal anti-NP antibodies that express different levels of serologically detected NPb idiotypic determinants, it was shown that anti-idiotypic suppressor T cells do not recognize the predominant NPb idiotypic determinants that are defined by serologic analysis. The implications for the possible expression and/or recognition of different sets of idiotypic determinants on T and B cells are discussed.
MeSH Terms
Animals
Antibodies, Monoclonal
Epitopes
Guinea Pigs
Haptens
Immunoglobulin Idiotypes/immunology
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Nitrophenols/immunology
Phenylacetates
T-Lymphocytes/immunology
T-Lymphocytes, Regulatory/immunology
Chemicals
Antibodies, Monoclonal
Epitopes
Haptens
Immunoglobulin Idiotypes
Nitrophenols
Phenylacetates
4-hydroxy-5-nitrophenyl acetic acid
References (20)
20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1981-11-01
Pages
1382-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186514
Subset
IM
Grants
NIAID NIH HHS · AI 16677 · United States
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