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PMID: 6454741 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses.

The Journal of experimental medicine ·Vol. 153 ·No. 4 ·1981-04-01 ·Pages 811-22

Sunday ME, Benacerraf B, Dorf ME

Abstract

In the current study, we examine the mechanism of suppression of cutaneous sensitivity (CS) responses to 4-hydroxy-3-nitrophenyl acetyl succinimide ester. Intravenous administration of haptenated syngeneic spleen cells induces a state of hapten-specific tolerance involving I-J bearing suppressor T cells that function at either the induction phase or the effector phase of the CS response. The effective phase suppressor cells (Tse) are genetically restricted by both Igh and H-2 region genes. However, a third cell population is also required in he immune lymphocyte population for immune suppression. This third cell population, termed Ts3, is an I-J+, cyclophosphamide-sensitive T cell, as shown by reconstitution experiments. Further, the Tse-Ts3 interaction is restricted by genes in he H-2 and Igh gene complexes. The results are discussed with respect to the pathway of cellular interactions leading to immuno suppression.

MeSH Terms
Animals Antibodies Antilymphocyte Serum/pharmacology Cyclophosphamide/pharmacology H-2 Antigens/genetics Haptens/immunology Hybrid Cells/immunology Hypersensitivity, Delayed/immunology Immune Tolerance Mice Nitrophenols/immunology Phenotype Phenylacetates T-Lymphocytes/immunology T-Lymphocytes, Regulatory/immunology
Chemicals
Antibodies Antilymphocyte Serum H-2 Antigens Haptens Nitrophenols Phenylacetates 4-hydroxy-5-nitrophenyl acetic acid Cyclophosphamide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sunday M E
Benacerraf B
Dorf M E
References (25)
25 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.153.4.811
Published
1981-04-01
Pages
811-22
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186128
Subset
IM
Grants
NIAID NIH HHS · AI-00152 · United States
NIAID NIH HHS · AI-16677 · United States
External Links
PubMed source DOI: 10.1084/jem.153.4.811 PMC Full Text View journal details
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