Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes.
The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical with respect to their expression of the same recurrent specificities. Taken together with results previously obtained, it is concluded that both major histocompatibility complex and Igh-linked genes affect the CTL specificity repertoire.
16 references, click to expand
-
T-cell idiotypes are linked to immunoglobulin heavy chain genes.Nature. 1976 Dec 16;264(5587):639-42 PMID: 137363
-
Antigen-binding, idiotypic T-lymphocyte receptors.Contemp Top Immunobiol. 1977;7:113-77 PMID: 69514
-
T cell receptor idiotypes are controlled by genes in the heavy chain linkage group and the major histocompatibility complex.Nature. 1977 Dec 22-29;270(5639):733-5 PMID: 413058
-
Expression and function of idiotypes of lymphocytes.Adv Immunol. 1978;26:195-254 PMID: 80953
-
The induction of cytolytic T lymphocytes with specificity for p-azophenylarsonate coupled syngeneic cells.J Immunol. 1978 Oct;121(4):1432-6 PMID: 81234
-
Immunological studies of T-cell receptors. II. Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex alloantigens.J Exp Med. 1979 Jan 1;149(1):234-43 PMID: 33224
-
Isolated hapten-binding receptors of sensitized lymphocytes. IV. Expression of immunoglobulin variable regions in (4-hydroxy-3-nitrophenyl) acetyl (NP)-specific receptors isolated from murine B and T lymphocytes.Eur J Immunol. 1979 Apr;9(4):332-8 PMID: 111953
-
Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire.J Exp Med. 1980 Jun 1;151(6):1386-97 PMID: 6155421
-
Genetic and serological analysis of the expression of crossreactive idiotypic determinants on anti-p-azobenzenarsonate antibodies and p-azobenzenarsonate-specific suppressor T cell factors.Proc Natl Acad Sci U S A. 1981 Feb;78(2):1143-7 PMID: 6165006
-
T lymphocytes specific for immunoglobulin allotype. II. Cloned Igh-1b-specific cytotoxic T cells.J Exp Med. 1981 Aug 1;154(2):491-500 PMID: 6973606
-
The T-cell receptor problem.Curr Top Microbiol Immunol. 1981;91:179-215 PMID: 6796337
-
Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: possible application to vaccine production.Clin Immunol Immunopathol. 1981 Dec;21(3):397-406 PMID: 6173154
-
Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes.J Exp Med. 1982 Feb 1;155(2):380-9 PMID: 6173455
-
Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells.J Exp Med. 1982 Feb 1;155(2):611-6 PMID: 6977010
-
Genetic and regulatory contributions of the major histocompatibility complex to the developing cytolytic T lymphocyte repertoire.J Immunol. 1982 Apr;128(4):1849-53 PMID: 7061852
-
Failure to demonstrate public idiotypes on cytolytic cells with specificity for NP-coupled syngeneic cells.Scand J Immunol. 1980;11(3):241-6 PMID: 9537051
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
