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PMID: 6181734 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Penicillin-resistant and penicillin-tolerant mutants of group A Streptococci.

Antimicrobial agents and chemotherapy ·Vol. 22 ·No. 1 ·1982-07-00 ·Pages 128-36

Gutmann L, Tomasz A

Abstract

Penicillin-resistant and penicillin-tolerant mutants have been isolated from group A streptococci mutagenized by ethyl methane sulfonate. The resistant mutants had an elevated minimal growth inhibitory concentration for benzylpenicillin (minimal inhibitory concentration, 0.2 microgram/ml, as compared with the minimal inhibitory concentration of 0.006 microgram/ml in the penicillin-susceptible parent strain); they also had an abnormal cellular morphology and showed altered penicillin-binding proteins. Penicillin-tolerant mutants were killed more slowly than were the parental cells during treatment with penicillin; they had virtually unchanged minimal inhibitory concentration values for penicillin and normal cellular morphology and penicillin-binding proteins.

MeSH Terms
Bacterial Proteins Carrier Proteins/metabolism Hexosyltransferases Muramoylpentapeptide Carboxypeptidase Mutation Penicillin Resistance Penicillin-Binding Proteins Penicillins/pharmacology Peptidyl Transferases RNA, Bacterial/biosynthesis Streptococcus pyogenes/drug effects Time Factors
Chemicals
Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins Penicillins RNA, Bacterial Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gutmann L
Tomasz A
References (18)
18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.22.1.128
Published
1982-07-00
Pages
128-36
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC183685
Subset
IM
Grants
NIAID NIH HHS · AI 16170 · United States
External Links
PubMed source DOI: 10.1128/AAC.22.1.128 PMC Full Text View journal details
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