The distribution of DR5, MT2, and MB3 specificities on human Ia subsets.
Human Ia molecules were isolated from cells of LG-38, an HLA-homozygous lymphoid cell line of DR5 specificity. Three Ia subsets could be distinguished and separated by using specific alloantisera and a monoclonal antibody with polymorphic reactivity. These subsets carried the specificities DR5 and MT2, MT2 alone and MB3 alone. The structure of the three molecular species was analyzed by microfingerprinting. The subset carrying only MT2 was similar, in both the component alpha and beta chains, to the major subset carrying DR5 and MT2, whereas the subset carrying MB3 was distinct in both chains from the other two subsets. These data are compatible with our previous findings obtained for the products of two Ia loci closely linked to the DR locus and provisionally called DC and BR; they also support the conclusion that the subset carrying only MT2 is an allelic product of the BR locus, whereas the MB3 subset is an allelic product of the DC locus. MT2 appears to be a shared specificity of DR and BR loci products.
26 references, click to expand
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
-
The complexity of the HL-A gene product. II. Possible evidence for a "public" determinant common to the first and second HL-A series.Transplantation. 1975 Feb;19(2):177-80 PMID: 47200
-
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.J Immunol. 1979 Jun;122(6):2232-7 PMID: 448125
-
Structural polymorphism of human DR antigens.Nature. 1979 May 31;279(5712):436-7 PMID: 16068184
-
Alloantigens of human lymphoid cell lines; 'human Ia-like antigens'. Alloantigenic activity and cell line, organ and tissue distribution as determined by radioimmunoassay.Immunology. 1977 Aug;33(2):217-30 PMID: 24587
-
A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.Somatic Cell Genet. 1977 Mar;3(2):231-6 PMID: 605383
-
Murine Ia and human DR antigens: homology of amino-terminal sequences.Proc Natl Acad Sci U S A. 1978 Aug;75(8):3953-6 PMID: 99745
-
Cross-reactivity between the first and second segregant series of the HLA system.Tissue Antigens. 1976 Feb;7(2):125-7 PMID: 1084062
-
Identification of an HLA-DR-associated system of B-cell alloantigens.Transplant Proc. 1979 Dec;11(4):1757-60 PMID: 93800
-
Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity.J Exp Med. 1975 Feb 1;141(2):374-91 PMID: 1089744
-
Analysis of HLA-DR polymorphism by two-dimensional peptide mapping.Proc Natl Acad Sci U S A. 1981 Jan;78(1):534-8 PMID: 6787592
-
Assessment of the specificity of human Ia alloantisera and alloantigens by the use of radioiodinated human Ia antigens.Tissue Antigens. 1982 Jul;20(1):1-21 PMID: 6957025
-
Three Ia species with different structures and alloantigenic determinants in an HLA-homozygous cell line.J Exp Med. 1983 Jan 1;157(1):231-47 PMID: 6401317
-
Direct evidence of homology between human DC-1 antigen and murine I-A molecules.Nature. 1982 Oct 28;299(5886):836-40 PMID: 6752724
-
A safe blood transfusion procedure for immunization against major histocompatibility complex determinants in man.Transplantation. 1978 Sep;26(3):150-2 PMID: 705871
-
[Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)].Hoppe Seylers Z Physiol Chem. 1981 Dec;362(12):1665-9 PMID: 6947956
-
Immunological dissection of human Ia molecules.J Exp Med. 1978 Dec 1;148(6):1592-611 PMID: 82605
-
HLA-DR antigens have polymorphic light chains and invariant heavy chains as assessed by lysine-containing tryptic peptide analysis.J Exp Med. 1980 Aug 1;152(2 Pt 2):37s-53s PMID: 6774044
-
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.Biochem J. 1963 Oct;89:114-23 PMID: 14097352
-
Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.J Exp Med. 1982 Aug 1;156(2):550-66 PMID: 6808075
-
Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.Proc Natl Acad Sci U S A. 1981 Jul;78(7):4566-70 PMID: 6974868
-
Further characterization of two "DR supertypic" specificities. Additional evidence that they reside on molecules different from those carrying HLA-DR locus specificities.Hum Immunol. 1981 Oct;3(2):93-108 PMID: 6173362
-
Molecular relationships of the human B cell alloantigens, MT2, MB3, MT4, and DR5.J Immunol. 1982 Apr;128(4):1809-18 PMID: 6174616
-
Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants.Nature. 1981 Jul 23;292(5821):357-60 PMID: 6166865
-
Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.Immunogenetics. 1980;10(2):151-67 PMID: 6932390
-
The genetic control of human Ia alloantigens: a three-loci model derived from the immunochemical analysis of 'supertypic' specificities.Immunol Rev. 1982;66:5-37 PMID: 6182090
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