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PMID: 6244869 Published · ppublish English Case Reports Journal Article

Epstein-Barr virus-positive Burkitt's lymphoma in a German woman during pregnancy.

Blut ·Vol. 40 ·No. 3 ·1980-03-00 ·Pages 167-77

Bornkamm GW, Kaduk B, Kachel G, Schneider U, Fresen KO, Schwanitz G, Hermanek P

Abstract

A fatal case of a Burkitt's lymphoma which occurred in a 34-year-old German woman during pregnancy is described. Nearly all organs showed either diffuse or nodular infiltration by tumor cells. Placenta and fetus were free of detectable tumor tissue. The patient had extremely high antibody titers (1 : 2056), both against Epstein-Barr virus capsid antigen (VCA) and the early antigen complex (EA). Within the tumor cells the Epstein-Barr virus-specific nuclear antigen EBNA and viral DNA was detected. A cell line established from a tumor biopsy displayed a translocation involving chromosomes 2 and 8. The role of Epstein-Barr virus in the development of Burkitt's lymphoma is discussed.

MeSH Terms
Adult Antibodies, Viral/analysis Burkitt Lymphoma/immunology Cell Line Chromosomes, Human, 1-3 Chromosomes, Human, 6-12 and X DNA, Viral/analysis Female Herpesvirus 4, Human/immunology Humans Pregnancy Pregnancy Complications/immunology Translocation, Genetic
Chemicals
Antibodies, Viral DNA, Viral
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Bornkamm G W
Kaduk B
Kachel G
Schneider U
Fresen K O
Schwanitz G
Hermanek P
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47 references, click to expand
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Article Info
Journal
Blut
Abbr.
Blut
ISSN
0006-5242
DOI
10.1007/BF01008574
Published
1980-03-00
Pages
167-77
Language
English
Region
Germany
NLM ID
0173401
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01008574
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