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PMID: 6249746 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Marrow-dependent cells depleted by 89Sr mediate genetic resistance to herpes simplex virus type 1 infection in mice.

Infection and immunity ·Vol. 28 ·No. 3 ·1980-06-00 ·Pages 1028-32

Lopez C, Ryshke R, Bennett M

Abstract

Adult mice resistant to infection with 10(6) plaque-forming units of a virulent strain of herpes simplex virus type 1 were treated with 89Sr to abrogate marrow-dependent cell functions. Treated mice were found to be much more susceptible to the herpes simplex virus type 1 infection than untreated mice. The virus persisted in the visceral tissues of 89Sr-treated mice for 3 or more days postinfection but not in those of untreated mice. The virus also spread to the spinal cords of treated but not untreated mice. A marrow-dependent cell appeared to mediate resistance to herpes simplex virus type 1 by controlling the infection early after inoculation and not allowing the infection spread to the central nervous system.

MeSH Terms
Animals Antigens, Viral/isolation & purification Bone Marrow/immunology,pathology Fluorescent Antibody Technique Herpes Simplex/genetics,immunology,pathology Immunity, Innate Mice Simplexvirus/immunology,isolation & purification Spinal Cord/immunology Strontium Radioisotopes/administration & dosage
Chemicals
Antigens, Viral Strontium Radioisotopes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lopez C
Ryshke R
Bennett M
References (20)
20 references, click to expand
  1. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.
    J Immunol. 1970 May;104(5):1155-9 PMID: 4315460
  2. Macrophages and age-dependent resistance to Herpes simplex virus in mice.
    J Immunol. 1970 May;104(5):1160-5 PMID: 4315461
  3. Peculiar immunobiology of bone marrow allografts. I. Graft rejection by irradiated responder mice.
    J Exp Med. 1971 Jul 1;134(1):83-102 PMID: 4397663
  4. Prevention of marrow allograft rejection with radioactive strontium: evidence for marrow-dependent effector cells.
    J Immunol. 1973 Feb;110(2):510-6 PMID: 4405320
  5. Abrogation of resistance to bone marrow grafts by silica particles. Prevention of the silica effect by the macrophage stabilizer poly-2-vinylpyridine N-oxide.
    J Immunol. 1974 Sep;113(3):798-803 PMID: 4369740
  6. Genetic control of resistance to allogeneic and xenogeneic bone-marrow grafts in mice.
    Transplant Proc. 1975 Jun;7(2):155-9 PMID: 165599
  7. Genetics of natural resistance to herpesvirus infections in mice.
    Nature. 1975 Nov 13;258(5531):152-3 PMID: 171586
  8. Selective elimination of marrow precursors with the bone-seeking isotope 89Sr: implications for hemopoiesis, lymphopoiesis, viral leukemogenesis and infection.
    J Reticuloendothel Soc. 1976 Jul;20(1):71-87 PMID: 781225
  9. Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.
    J Immunol. 1977 Apr;118(4):1503-6 PMID: 300411
  10. Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus types 1 and 2.
    J Infect Dis. 1977 May;135(5):744-52 PMID: 192810
  11. Abrogation of resistance to foreign bone marrow grafts by carrageenans. I. Studies with the anti-macrophage agent seakem carrageenan.
    J Immunol. 1977 Aug;119(2):483-7 PMID: 196023
  12. Effect of silica on the pathogenic distinction between herpes simplex virus type 1 and 2 hepatitis in mice.
    Infect Immun. 1977 Aug;17(2):274-7 PMID: 197016
  13. Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts.
    Eur J Immunol. 1977 Sep;7(9):655-63 PMID: 336380
  14. In vitro activation of suppressor cells from spleens of mice treated with radioactive strontium.
    J Immunol. 1978 Aug;121(2):505-12 PMID: 681747
  15. Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice.
    Infect Immun. 1979 Feb;23(2):432-7 PMID: 217830
  16. Immunological nature of genetic resistance of mice to herpes simplex virus type 1 infection.
    IARC Sci Publ. 1978;(24 Pt 2):775-81 PMID: 109389
  17. Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice.
    J Exp Med. 1979 May 1;149(5):1117-33 PMID: 221611
  18. Natural killing of herpes simplex virus type 1-infected target cells: normal human responses and influence of antiviral antibody.
    Infect Immun. 1979 Oct;26(1):49-56 PMID: 227799
  19. Cellular resistance to infection.
    J Exp Med. 1962 Sep 1;116:381-406 PMID: 14467923
  20. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE.
    J Exp Med. 1964 Sep 1;120:359-74 PMID: 14207057
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.28.3.1028-1032.1980
Published
1980-06-00
Pages
1028-32
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC551053
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.28.3.1028-1032.1980 PMC Full Text View journal details
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