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PMID: 6262729 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer.

Nucleic acids research ·Vol. 9 ·No. 6 ·1981-03-25 ·Pages 1365-81

Yamawaki-Kataoka Y, Miyata T, Honjo T

Abstract

We have determined the complete nucleotide sequence (1990 base pairs) of mouse immunoglobulin gamma 2a gene, and compared it with the sequences of other gamma subclass genes so far sequenced, i.e. gamma 1 and gamma 2b genes. Divergence of the nucleotide sequence between a compared pair of the gamma genes varies extensively among different segments of the gene. For example, comparison of the gamma 2a and gamma 2b genes has revealed a remarkable homology in a long continuous segment (about 900 bases) that covers from the 3' portion of the first intervening sequence to the third intervening sequence. However, there is no particular segment of the gamma gene that is conserved universally among the three gamma genes. These findings suggest that, during their evolution, segments of the gamma genes had been scrambled between different subclass genes through recombinations within intervening sequences, thus providing further evidence for the intervening sequence-mediated domain transfer hypothesis. We have discussed several possible phylogenic trees which can explain the difference of divergence in various segments of the gamma genes.

MeSH Terms
Animals Base Sequence Biological Evolution DNA Restriction Enzymes DNA, Recombinant/immunology Escherichia coli/immunology Genes Immunoglobulin G/genetics Immunoglobulin Heavy Chains/genetics Mice Plasmids
Chemicals
DNA, Recombinant Immunoglobulin G Immunoglobulin Heavy Chains DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yamawaki-Kataoka Y
Miyata T
Honjo T
References (31)
31 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/9.6.1365
Published
1981-03-25
Pages
1365-81
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326763
Subset
IM
Databases
GENBANK
J00470
External Links
PubMed source DOI: 10.1093/nar/9.6.1365 PMC Full Text View journal details
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