Two virus-specific rna species are present in cells transformed by defective leukemia virus OK10.

Journal of virology ·Vol. 40 ·No. 1 ·1981-10-00 ·Pages 301-4

Chiswell DJ, Ramsay G, Hayman MJ

Abstract

OK10 is a defective leukemia virus which shares some biological and biochemical properties of avian myelocytomatosis virus (MC29). We investigated the pattern of transcription of OK10 in both quail and chicken cells. In both cell types, OK10 produced two polyadenylated RNA species of 8.6 and 3.5 kilobases, which both contained sequences derived from the 5' end of the genome and also the presumed transforming gene (myc). This is a novel form of expression for defective leukemia viruses of the MC29 subgroup and may indicate that there is an as-yet-unidentified protein produced in OK10-infected cells which may be involved in transformation.

MeSH Terms

Animals Antigens, Viral/genetics Avian Leukosis Virus/genetics Cell Transformation, Viral Cells, Cultured Defective Viruses/genetics Gene Products, gag Genes, Viral Quail RNA, Messenger/genetics RNA, Viral/genetics Transcription, Genetic Viral Proteins/genetics

Chemicals

Antigens, Viral Gene Products, gag RNA, Messenger RNA, Viral Viral Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chiswell D J

Ramsay G

Hayman M J

References (24)

24 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.40.1.301-304.1981

Published

1981-10-00

Pages

301-4

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC256620

Subset

External Links

PubMed source DOI: 10.1128/JVI.40.1.301-304.1981 PMC Full Text View journal details

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Two virus-specific rna species are present in cells transformed by defective leukemia virus OK10.

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