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PMID: 6285864 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The virion RNA species of the Kirsten murine sarcoma-leukemia virus complex released from a clonally related series of mouse cells.

Archives of virology ·Vol. 72 ·No. 1-2 ·1982-00-00 ·Pages 35-46

Clewley JP, Avery RJ

Abstract

We have characterized the virion RNA species of Kirsten sarcoma (KiSV) and Kirsten leukemia (KiLV) viruses released from a clonally related series of mouse cells (14). We have identified the KiLV and KiSV genome RNAs. In addition to the viral RNA species we find large amounts of a virus-like RNA (VL30 RNA), which is heterogeneous and shows variability in its expression. The amount of VL30 RNA in virions does not correlate with the state of transformation of the cells releasing the virus or the ability of the virus to transform other cells. Characterization of RNA rescued from non-producer cells has revealed a sarcoma virus (KiSV CB3) with an oligonucleotide fingerprint different from that of a standard KiSV RNA, suggesting that it has lost some viral sequences. The oligonucleotide fingerprints of KiLV and VL30 RNAs are distinct from each other and from those reported for other murine leukemia virus RNAs.

MeSH Terms
Animals Cell Line Cell Transformation, Viral Clone Cells Kirsten murine sarcoma virus/genetics,physiology Leukemia Virus, Murine/genetics Mice Oligoribonucleotides/analysis RNA, Viral/analysis Sarcoma Viruses, Murine/genetics Virion/genetics
Chemicals
Oligoribonucleotides RNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clewley J P
Avery R J
References (19)
19 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01314448
Published
1982-00-00
Pages
35-46
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01314448 View journal details
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