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PMID: 6292865 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure and evolution of the heavy chain from rat immunoglobulin E.

Nucleic acids research ·Vol. 10 ·No. 19 ·1982-10-11 ·Pages 6041-9

Hellman L, Pettersson U, Engström A, Karlsson T, Bennich H

Abstract

The nucleotide sequence of the rat epsilon-chain mRNA has been determined by sequencing cloned cDNA copies of the mRNA. The established sequence covers the coding region, the 3'-non coding region and most of the 5' non-coding region. A comparison with the nucleotide sequence of the human epsilon-chain constant region reveals that C3 and C4 are the most highly conserved domains. The rat epsilon-chain contains a C-terminal decapeptide which is not present in the human counterpart.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Cell Line Cloning, Molecular DNA DNA Restriction Enzymes Immunoglobulin E/genetics Immunoglobulin Heavy Chains/genetics Neoplasms, Experimental/immunology RNA, Messenger/genetics Rats
Chemicals
Immunoglobulin Heavy Chains RNA, Messenger Immunoglobulin E DNA DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hellman L
Pettersson U
Engström A
Karlsson T
Bennich H
References (10)
10 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.19.6041
Published
1982-10-11
Pages
6041-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320949
Subset
IM
Databases
GENBANK
J00742, J00743, J00744, K00390
External Links
PubMed source DOI: 10.1093/nar/10.19.6041 PMC Full Text View journal details
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