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PMID: 6299957 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta.

Infection and immunity ·Vol. 40 ·No. 1 ·1983-04-00 ·Pages 172-6

Dolei A, Capobianchi MR, Ameglio F

Abstract

Human interferon-gamma was more effective than interferon-beta or -alpha in stimulating production of immunoassociated antigens; HLA-A, -B, and -C; and beta(2)-microglobulin in human M14 and Namalva cells. The comparison was made on the basis of antiviral units, and the stimulation could be abolished by treatment of the interferon-gamma preparation with pH 2 or anti-interferon-gamma serum.

MeSH Terms

Animals Cell Line HLA Antigens/analysis,immunology HLA-A Antigens HLA-B Antigens HLA-C Antigens Histocompatibility Antigens Class II/analysis,immunology Humans Interferon Type I/physiology Rabbits Vesicular stomatitis Indiana virus/growth & development Virus Replication beta 2-Microglobulin/analysis,immunology

Chemicals

HLA Antigens HLA-A Antigens HLA-B Antigens HLA-C Antigens Histocompatibility Antigens Class II Interferon Type I beta 2-Microglobulin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dolei A

Capobianchi M R

Ameglio F

References (25)

25 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.40.1.172-176.1983

Published

1983-04-00

Pages

172-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC264832

Subset

External Links

PubMed source DOI: 10.1128/iai.40.1.172-176.1983 PMC Full Text View journal details

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Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta.

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