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PMID: 6310482 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Block by Cs of K current iK1 and of carbachol induced K current iCch in frog atrium.

Pflugers Archiv : European journal of physiology ·Vol. 397 ·No. 4 ·1983-06-01 ·Pages 295-9

Argibay JA, Dutey P, Ildefonse M, Ojeda C, Rougier O, Tourneur Y

Abstract

1. In frog atrium, Cs ions block both the inward rectifier iK1 and the carbachol induced K current iCch. 2. Both iK1 and iCch display a high affinity for Cs with a K0.5 of 4 X 10(-5) M for iK1 and of 8 X 10(-5) M for iCch at V = -50 mV. 3. Block of both iK1 and iCch is strongly voltage dependent. When fitted by the block model of Woodhull (1973), delta is greater than 1 for the two currents. 4. From these similarities, action of Cch on frog atrium K permeability could be interpreted as a modification of iK1.

MeSH Terms
Animals Carbachol/pharmacology Cesium/pharmacology Dose-Response Relationship, Drug Heart/physiology Heart Atria Ion Channels/drug effects Isotonic Solutions/pharmacology Potassium/metabolism Rana esculenta Ringer's Solution
Chemicals
Ion Channels Isotonic Solutions Cesium Ringer's Solution Carbachol Potassium
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Argibay J A
Dutey P
Ildefonse M
Ojeda C
Rougier O
Tourneur Y
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24 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00580264
Published
1983-06-01
Pages
295-9
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00580264 View journal details
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