On the genetic length of the short arm of the human X chromosome.

Human genetics ·Vol. 65 ·No. 1 ·1983-00-00 ·Pages 53-5

Ropers HH, Wieacker P, Wienker TF, Davies K, Williamson R

Abstract

Published estimates of the length of the human X chromosome are unreliable because they are based on scanty linkage data and complex assumptions about the frequency and distribution of chiasmata in female meiosis. In recent months we have established linkage between restriction fragment length polymorphisms (RFLPs) and several genes on the short arm of the X chromosome. These and previous data can be combined to construct a continuous linkage map spanning the short arm from the Xg gene to the centromere. They suggest that the genetic length of the Xg-Xcen segment may be in the order of 75-90 cM.

MeSH Terms

Chromosome Mapping DNA Restriction Enzymes/genetics Female Genetic Linkage Genetic Markers Glucosephosphate Dehydrogenase/genetics Humans Lod Score Male Muscular Dystrophies/genetics X Chromosome

Chemicals

Genetic Markers Glucosephosphate Dehydrogenase DNA Restriction Enzymes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ropers H H

Wieacker P

Wienker T F

Davies K

Williamson R

References (29)

29 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00285028

Published

1983-00-00

Pages

53-5

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00285028 View journal details

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On the genetic length of the short arm of the human X chromosome.

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