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PMID: 6319741 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An Epstein-Barr virus DNA fragment encodes messages for the two major envelope glycoproteins (gp350/300 and gp220/200).

Journal of virology ·Vol. 49 ·No. 2 ·1984-02-00 ·Pages 413-7

Hummel M, Thorley-Lawson D, Kieff E

Abstract

The genes encoding the two major Epstein-Barr virus glycoproteins (gp350/300 and gp220/200) have been mapped to a 5-kilobase fragment of the viral genome (BamHI-L). This fragment encodes 3.4- and 2.8-kilobase RNAs which translate proteins of 135 and 100 kilodaltons, respectively. Both proteins react with antiserum specific for gp350/300 and gp220/200. The 135-kilodalton protein is identical in size to the nascent polypeptide precursor to gp350/300, and the 100-kilodalton protein is the expected size of the polypeptide precursor to gp220/200.

MeSH Terms
Animals Base Sequence DNA Restriction Enzymes DNA, Viral/genetics Genes Genes, Viral Herpesvirus 4, Human/genetics Molecular Weight Nucleic Acid Hybridization Protein Biosynthesis RNA, Viral/genetics Viral Envelope Proteins/genetics
Chemicals
DNA, Viral RNA, Viral Viral Envelope Proteins DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hummel M
Thorley-Lawson D
Kieff E
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31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.49.2.413-417.1984
Published
1984-02-00
Pages
413-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255481
Subset
IM
Grants
NIAID NIH HHS · AI 15310 · United States
NCI NIH HHS · CA 17281 · United States
NCI NIH HHS · CA 19264 · United States
External Links
PubMed source DOI: 10.1128/JVI.49.2.413-417.1984 PMC Full Text View journal details
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