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PMID: 6321780 Published · ppublish English Journal Article

Large-T-antigen-p53 complex formation is not cold sensitive in a cold-sensitive transformant induced by simian virus 40 mutant tsA1499.

Journal of virology ·Vol. 49 ·No. 3 ·1984-03-00 ·Pages 997-1001

Bouck N, Fikes J, Rundell MK

Abstract

F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished.

MeSH Terms
Animals Antigens, Polyomavirus Transforming Cell Line Cell Transformation, Viral Cold Temperature Mutation Phenotype Phosphoproteins/metabolism Rats Simian virus 40/genetics Tumor Suppressor Protein p53 Viral Proteins/metabolism
Chemicals
Antigens, Polyomavirus Transforming Phosphoproteins Tumor Suppressor Protein p53 Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bouck N
Fikes J
Rundell M K
References (48)
48 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.49.3.997-1001.1984
Published
1984-03-00
Pages
997-1001
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255564
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.49.3.997-1001.1984 PMC Full Text View journal details
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