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PMID: 6322186 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure of a human gastrin gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 4 ·1984-02-00 ·Pages 1067-9

Wiborg O, Berglund L, Boel E, Norris F, Norris K, Rehfeld JF, Marcker KA, Vuust J

Abstract

A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptide, from the region coding for the major amino-terminal portion of the gastrin precursor. The 5' flanking region of the gene contains the conserved sequences, T-A-T-A-A and G-A-C-T-C-A-T-A-T, in positions similar to those of other eukaryotic genes.

MeSH Terms
Amino Acid Sequence Base Composition Base Sequence Cloning, Molecular Codon DNA/analysis DNA Restriction Enzymes Gastrins/genetics Genes Humans Nucleic Acid Hybridization
Chemicals
Codon Gastrins DNA DNA Restriction Enzymes
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wiborg O
Berglund L
Boel E
Norris F
Norris K
Rehfeld J F
Marcker K A
Vuust J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.4.1067
Published
1984-02-00
Pages
1067-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC344765
Subset
IM
Databases
GENBANK
J00147, K01253, K01254
External Links
PubMed source DOI: 10.1073/pnas.81.4.1067 PMC Full Text View journal details
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