Theoretical studies of the selective binding to DNA of two non-intercalating ligands: netropsin and SN 18071.
A theoretical study of the binding to DNA of netropsin and a bisquaternary ammonium heterocycle, SN 18071, is undertaken with an energy minimizing program based on empirical potential functions. The positioning of the ligand is achieved by force and torque calculations and its internal flexibility is taken into account. The binding preference of both drugs studied for the AT minor groove of B-DNA is shown to depend on both the electrostatic potential generated by the base sequence and the quality of the steric fit of the ligand in the groove. Ligand-DNA hydrogen bonds are shown to aid binding, but not to be essential in establishing binding preferences.
17 references, click to expand
-
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.Nucleic Acids Res. 1974 Mar;1(3):503-30 PMID: 10793682
-
Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid.J Biol Chem. 1974 Nov 10;249(21):6719-31 PMID: 4371420
-
Effects of the antibiotics netropsin and distamycin A on the structure and function of nucleic acids.Prog Nucleic Acid Res Mol Biol. 1975;15(0):285-318 PMID: 1094496
-
Netropsin, a DNA-binding oligopeptide structural and binding studies.Biochim Biophys Acta. 1979 Jan 26;561(1):124-31 PMID: 420847
-
Influence of nucleotide sequence on dA.dT-specific binding of Netropsin to double stranded DNA.Nucleic Acids Res. 1979 Jun 25;6(8):2831-7 PMID: 461206
-
Netropsin . dG-dG-dA-dA-dT-dT-dC-dC complex. Antibiotic binding at adenine . thymine base pairs in the minor groove of the self-complementary octanucleotide duplex.Eur J Biochem. 1979 Sep;99(2):369-78 PMID: 499206
-
Left-handed DNA helices.Nature. 1980 Feb 21;283(5749):743-5 PMID: 7354864
-
Existence of an extended series of antitumor compounds which bind to deoxyribonucleic acid by nonintercalative means.Biochemistry. 1980 Mar 18;19(6):1101-6 PMID: 7189408
-
Magnetic circular dichroism study of the binding of netropsin and distamycin A with DNA.Biochim Biophys Acta. 1980 Apr 30;607(2):232-46 PMID: 6245701
-
Protection of (dA.dT) cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin.Nucleic Acids Res. 1980 Jul 11;8(13):2999-3010 PMID: 6253900
-
Molecular electrostatic potential of the nucleic acids.Q Rev Biophys. 1981 Aug;14(3):289-380 PMID: 7027300
-
Differential stabilization by netropsin of inducible B-like conformations in deoxyribo-, ribo- and 2'-deoxy-2'-fluororibo-adenosine containing duplexes of (dA)n . (dT)n and (dA)n . (dU)na.Nucleic Acids Res. 1982 Mar 11;10(5):1721-32 PMID: 6280155
-
Nonintercalative DNA-binding antitumour compounds.Mol Cell Biochem. 1982 Apr 2;43(3):167-81 PMID: 6283334
-
The effects of countercation screening on the electrostatic potential of DNA. The rôle of the nucleic acid conformation.FEBS Lett. 1982 Jun 7;142(2):271-4 PMID: 7106290
-
Specific interaction of netropsin, distamycin-3 and analogs with LC duplexes: reversion towards the B form of the 2'-deoxy-.2'-deoxy-2'-fluoro-hybrid duplexes upon specific interaction with netropsin, distamycin-3 and analogs.Nucleic Acids Res. 1982 Oct 11;10(19):6147-61 PMID: 6292869
-
Antibiotic-DNA interactions: intermolecular nuclear Overhauser effects in the netropsin-d(C-G-C-G-A-A-T-T-C-G-C-G) complex in solution.Proc Natl Acad Sci U S A. 1982 Nov;79(21):6424-8 PMID: 6292900
-
Calorimetric and spectroscopic investigation of drug-DNA interactions. I. The binding of netropsin to poly d(AT).Nucleic Acids Res. 1983 May 11;11(9):2857-70 PMID: 6304658
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
