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PMID: 6417007 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

NH2-terminal sequence of the alpha and beta chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules.

Immunogenetics ·Vol. 18 ·No. 5 ·1983-00-00 ·Pages 453-9

Bono MR, Strominger JL

Abstract

The DC-1 antigen has been isolated from the JY cell line (DR4, w6). The amino terminal sequences of its alpha and beta chains are both reported and are homologous to the murine I-A antigens. The JY and previously reported LB DC-1 alpha chain sequences appear to be variants of the DC alpha chains reported by other authors. The JY DC-1 beta chain sequence appears to be identical with that deduced from a beta chain cDNA clone and thus identifies this clone. The JY and LB DC-1 beta-chains are clearly different since the latter has a blocked amino terminus.

MeSH Terms
Amino Acid Sequence Animals B-Lymphocytes/immunology Cell Line Electrophoresis, Polyacrylamide Gel Genes, MHC Class II HLA-DR Antigens Humans Leukemia, Lymphoid Macromolecular Substances Mice Molecular Weight Species Specificity
Chemicals
HLA-DR Antigens Macromolecular Substances
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bono M R
Strominger J L
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21 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00364387
Published
1983-00-00
Pages
453-9
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI 10736 · United States
NIADDK NIH HHS · AM 30241 · United States
External Links
PubMed source DOI: 10.1007/BF00364387 View journal details
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