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PMID: 646466 Published · ppublish English Journal Article

Immune response inversion after hyperimmunisation. Possible mechanism in the pathogenesis of HLA-linked diseases.

Annals of the rheumatic diseases ·Vol. 37 ·No. 2 ·1978-04-00 ·Pages 152-8

Young CR, Ebringer A, Archer JR

Abstract

The crosstolerance hypothesis suggests that animals sharing antigens with some microorganisms will produce low antibody levels in the early part and high levels in the latter part of an infection. Antibody responses have been measured in high responder B10.M and B10.D2 mice and low responder C3H and A.Thy-1.1, as well as F1 hybrids (B10.M X A.Thy-1.1) and (B10.M X C3H/He), after repeated immunisation with the antigen ferritin, involving altogether 483 mice. An inversion in the immune response was found to occur and similar delayed high antibody responses have been described in rheumatic fever. It is suggested a mechanism of immune inversion may operate in the pathogenesis of HLA and blood group-linked diseases.

MeSH Terms
Animals Antibody Formation Cross Reactions Ferritins/immunology HLA Antigens Immune Tolerance Immunization, Secondary Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Mice
Chemicals
HLA Antigens Immunoglobulin G Immunoglobulin M Ferritins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Young C R
Ebringer A
Archer J R
References (22)
22 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.37.2.152
Published
1978-04-00
Pages
152-8
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1001181
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.37.2.152 PMC Full Text View journal details
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