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PMID: 6602202 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells.

The Journal of experimental medicine ·Vol. 157 ·No. 6 ·1983-06-01 ·Pages 1906-19

Clayberger C, Dekruyff RH, Aisenberg J, Cantor H

Abstract

Hapten-reactive inducer T cell clones can be divided into two groups based on their activation specificity. The first and largest group is conjugate specific. These clones are activated only by hapten coupled to the same carrier protein used for in vitro selection. The second group, which is quite rare, is hapten specific. Clones of this type are activated by hapten coupled to all foreign and autologus proteins tested. Both types of clones corecognize soluble antigen in association with products of the I-A locus. The hapten-specific cells were used to analyze the molecular basis of I-A vs. I-E gene control. The physiologic significance of hapten- and carrier-specific inducer T cells in the response to foreign antigens and autoantigens is discussed.

MeSH Terms
Animals Clone Cells/immunology Haptens/immunology Histocompatibility Antigens Class II/immunology Lymphocyte Activation Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Nitrophenols/immunology Phenylacetates T-Lymphocytes/immunology Trinitrobenzenes/immunology
Chemicals
Haptens Histocompatibility Antigens Class II Nitrophenols Phenylacetates Trinitrobenzenes 4-hydroxy-5-nitrophenyl acetic acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Clayberger C
Dekruyff R H
Aisenberg J
Cantor H
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34 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.157.6.1906
Published
1983-06-01
Pages
1906-19
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187041
Subset
IM
Grants
NIAID NIH HHS · AI12184 · United States
NIAID NIH HHS · AI13600 · United States
NCI NIH HHS · CA26695 · United States
External Links
PubMed source DOI: 10.1084/jem.157.6.1906 PMC Full Text View journal details
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