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PMID: 6605930 Published · ppublish English Comparative Study Journal Article

Modulation of myelopoiesis in vivo by synthetic adjuvant-active muramyl peptides: induction of colony-stimulating activity and stimulation of stem cell proliferation.

Infection and immunity ·Vol. 42 ·No. 3 ·1983-12-00 ·Pages 1081-5

Galelli A, Chedid L

Abstract

Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a proliferation of multipotential stem cells in the bone marrow, and an expansion of granulocyte-macrophage progenitors in the spleen. In contrast, the adjuvant-inactive stereoisomer MDP(D-D) induced only low levels of circulating colony-stimulating activity. Thus, MDP or MDP-butyl-ester injection could induce a greater number of macrophages and therefore enhance both specific and nonspecific immunity.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives,pharmacology Adjuvants, Immunologic/pharmacology Animals Bone Marrow/drug effects Cell Division/drug effects Colony-Stimulating Factors/blood Female Hematopoiesis/drug effects Mice Mice, Inbred DBA Stem Cells/drug effects
Chemicals
Adjuvants, Immunologic Colony-Stimulating Factors Acetylmuramyl-Alanyl-Isoglutamine murabutide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Galelli A
Chedid L
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.42.3.1081-1085.1983
Published
1983-12-00
Pages
1081-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264410
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.42.3.1081-1085.1983 PMC Full Text View journal details
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