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PMID: 6667677 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation.

The EMBO journal ·Vol. 2 ·No. 12 ·1983-00-00 ·Pages 2281-3

Davis M, Malcolm S, Hall A, Marshall CJ

Abstract

The N-ras gene is a transforming gene isolated from a variety of human tumour cell lines and is a member of a family of related ras genes. Somatic cell hybrids have previously shown that the N-ras gene is located on chromosome 1. We have confirmed this localisation by in situ hybridisation to metaphase preparations of lymphocytes and localised the gene to the region 1cen - p21. A survey has found 47 reported cases of malignancy involving deletions in the short arm of chromosome 1. Fifteen of the 47 involved a deletion in this region.

MeSH Terms
Chromosome Mapping Chromosomes, Human, 1-3 Humans Lymphocytes/physiology Nucleic Acid Hybridization Oncogenes Protein Biosynthesis
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Davis M
Malcolm S
Hall A
Marshall C J
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31 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1983-00-00
Pages
2281-3
Language
English
Region
England
NLM ID
8208664
PMCID
PMC555446
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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