Enhancement of postreplication repair in ultraviolet-light-irradiated Chinese hamster cells by irradiation in G2 or S-phase.

Biophysical journal ·Vol. 23 ·No. 1 ·1978-07-00 ·Pages 71-8

D'Ambrosio SM, Aebersold PM, Setlow RB

Abstract

Postreplication repair in synchronous Chinese hamster cells was determined after split doses of ultraviolet (UV) radiation. Repair was enhanced by irradiation of cells in G2 or S-phase with a small dose of UV radiation at least 1.5 h before a three-fold larger dose of UV. There was significantly greater enhancement when the first dose was given in G2 than when it was given in the S-phase 0.5-1.5 h before the test dose. These data indicate that enhancement of postreplication repair does not require active DNA replication and qualitatively is independent of when in the cell cycle the cells are irradiated.

MeSH Terms

Animals Cell Cycle Cells, Cultured Cricetinae DNA Repair/radiation effects DNA Replication Ultraviolet Rays

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

D'Ambrosio S M

Aebersold P M

Setlow R B

References (16)

16 references, click to expand

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Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(78)85433-2

Published

1978-07-00

Pages

71-8

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1473550

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(78)85433-2 PMC Full Text View journal details

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Enhancement of postreplication repair in ultraviolet-light-irradiated Chinese hamster cells by irradiation in G2 or S-phase.

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