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PMID: 6684766 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chromosomal localization of the human c-fms oncogene.

Nucleic acids research ·Vol. 11 ·No. 18 ·1983-09-24 ·Pages 6331-9

Groffen J, Heisterkamp N, Spurr N, Dana S, Wasmuth JJ, Stephenson JR

Abstract

A molecular probe was prepared with specificity for the human cellular homologue of transforming sequences represented within the McDonough strain of feline sarcoma virus (v-fms). By analysis of a series of mouse-human somatic cell hybrids containing variable complements of human chromosomes it was possible to assign this human oncogene, designated c-fms, to chromosome 5. Regional localization of c-fms to band q34 on chromosome 5 was accomplished by analysis of Chinese hamster-human cell hybrids containing as their only human components, terminal and interstitial deleted forms of chromosome 5. The localization of c-fms to chromosome 5 (q34) is of interest in view of reports of a specific, apparently interstitial, deletion involving approximately two thirds of the q arm of chromosome 5 in acute myelogenous leukemia cells.

MeSH Terms
Animals Base Sequence Cats Cell Line Cell Transformation, Neoplastic Cells, Cultured Chromosome Mapping Chromosomes, Human/analysis Cloning, Molecular Humans Hybrid Cells/metabolism Mice Nucleic Acid Hybridization Oncogenes Retroviridae/genetics
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Groffen J
Heisterkamp N
Spurr N
Dana S
Wasmuth J J
Stephenson J R
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.18.6331
Published
1983-09-24
Pages
6331-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326376
Subset
IM
Grants
NIGMS NIH HHS · GM-25339 · United States
NCI NIH HHS · N0I-CO-76380 · United States
External Links
PubMed source DOI: 10.1093/nar/11.18.6331 PMC Full Text View journal details
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