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PMID: 6776490 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA.

Nucleic acids research ·Vol. 8 ·No. 4 ·1980-02-25 ·Pages 703-13

Matthyssens G, Rabbitts TH

Abstract

The 3' terminal nucleotide sequence of two clones containing DNA complementary to mu chain mRNA of IgM-secreting cells has been determined. The sequence shows a termination codon (UGA) adjacent to the terminal tyrosine codon for the secreted protein and a 3' non-coding region of at least 106 bases. The primary translation product of this mu chain mRNA seems to terminate at the tyrosine of the secreted protein.

MeSH Terms
Animals Base Sequence Cloning, Molecular Codon DNA, Recombinant Immunoglobulin Heavy Chains/genetics Immunoglobulin M/genetics Immunoglobulin mu-Chains/genetics Mice Peptide Chain Termination, Translational RNA, Messenger/genetics
Chemicals
Codon DNA, Recombinant Immunoglobulin Heavy Chains Immunoglobulin M Immunoglobulin mu-Chains RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Matthyssens G
Rabbitts T H
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43 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
Published
1980-02-25
Pages
703-13
Language
English
Region
England
NLM ID
0411011
PMCID
PMC327304
Subset
IM
Databases
GENBANK
J00443
External Links
PubMed source PMC Full Text View journal details
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