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PMID: 6800944 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor.

Immunogenetics ·Vol. 14 ·No. 3-4 ·1981-00-00 ·Pages 263-72

Russell JH, Dobos CB, Graff RJ, Taylor BA

Abstract

Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.

MeSH Terms
Animals Antibodies, Neoplasm/genetics Cross Reactions Genes Genes, MHC Class II Genetic Linkage Hair Color Mice Mice, Inbred BALB C/genetics Mice, Inbred DBA/genetics Neoplasms, Experimental/immunology Phenotype Plasmacytoma/immunology
Chemicals
Antibodies, Neoplasm
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Russell J H
Dobos C B
Graff R J
Taylor B A
References (22)
22 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00342195
Published
1981-00-00
Pages
263-72
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
PHS HHS · 5S074R0538918 · United States
NIAID NIH HHS · AI07437 · United States
NIGMS NIH HHS · GM18684 · United States
External Links
PubMed source DOI: 10.1007/BF00342195 View journal details
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