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PMID: 680795 Published · ppublish English Journal Article

The binding of human and guinea-pig IgG subclasses to homologous macrophage and monocyte Fc receptors.

Immunology ·Vol. 35 ·No. 1 ·1978-07-00 ·Pages 115-23

Alexander MD, Andrews JA, Leslie RG, Wood NJ

Abstract

Guinea-pig IgG2 and IgT1 bind to contiguous Fc receptors on homologous peritoneal macrophages. Equilibrium association constants determined for the binding of human IgG subclasses to homologous peripheral blood monocytes show that the order of binding is IgG1 greater than IgG3 greater than IgG4 greater than IgG2. Direct binding and rosette assay techniques independently established that both guinea-pig IgG2 and human IgG bind to homologous macrophage-monocyte Fc receptors through a site present in whole Fc (CH2. CH3)2, but absent in pFc' subfragments (CH3)2.

MeSH Terms
Animals Antibody Specificity Guinea Pigs Humans Immunoglobulin Fc Fragments Immunoglobulin G Macrophages/immunology Monocytes/immunology Rosette Formation
Chemicals
Immunoglobulin Fc Fragments Immunoglobulin G
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Alexander M D
Andrews J A
Leslie R G
Wood N J
References (26)
26 references, click to expand
  1. Correlation between the exposure of aromatic chromophores at the surface of the Fc domains of immunoglobulin G and their ability to bind complement.
    Biochemistry. 1977 Jan 25;16(2):233-40 PMID: 13808
  2. The presence of two Fc receptors on mouse macrophages: evidence from a variant cell line and differential trypsin sensitivity.
    J Exp Med. 1977 Apr 1;145(4):931-45 PMID: 323399
  3. Catabolism and biologic properties of two species of rat IgG2a Fc fragments.
    J Immunol. 1977 Feb;118(2):395-400 PMID: 320257
  4. Cytophilic activity of enzymatically derived fragments of guinea pig IgG2.
    Eur J Immunol. 1976 Feb;6(2):101-7 PMID: 786696
  5. Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype.
    Eur J Immunol. 1974 Apr;4(4):296-302 PMID: 4546826
  6. Complement fixing and macrophage opsonizing activities associated with beta2 microglobulin.
    Immunol Commun. 1974;3(1):19-34 PMID: 4132700
  7. The products from papain and pepsin hydrolyses of guinea-pig immunoglobulins gamma 1G and gamma 2 G.
    Biochem J. 1971 Mar;121(5):829-37 PMID: 4107091
  8. Properties of antibodies cytophilic for macrophages.
    J Exp Med. 1966 Jan 1;123(1):119-44 PMID: 4159249
  9. The use of purified 125-I-labelled anti-gamma globulin in the determination of the number of D antigen sites on red cells of different phenotypes.
    Vox Sang. 1965 Nov-Dec;10(6):675-86 PMID: 4159466
  10. Characterization of a plasmin-digest fragment of rabbit immunoglobulin gamma that binds antigen and complement.
    Biochem J. 1975 Feb;145(2):177-83 PMID: 239679
  11. Cytophilic activity of IgG2 from sera of unimmunized guinea-pigs.
    Immunology. 1974 Oct;27(4):577-87 PMID: 4435833
  12. Localisation of monocyte binding site of human immunoglobulin G.
    Nature. 1974 Mar 15;248(445):228-30 PMID: 4819417
  13. The macrophage receptor for IgG: number and affinity of binding sites.
    J Immunol. 1973 Jun;110(6):1455-63 PMID: 4712920
  14. The cytophilic activity of human immunoglobulins.
    J Immunol. 1970 Aug;105(2):362-9 PMID: 4915774
  15. The structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the Cgamma2 and Cgamma3 homology regions of human immunoglobulin G1.
    J Immunol. 1976 Feb;116(2):518-26 PMID: 814165
  16. Biologic activities of rabbit immunoglobulin G in relation to domains of the Fc region.
    J Immunol. 1976 May;116(5):1265-71 PMID: 818312
  17. CH3 domain of IgG as binding site to Fc receptor on mouse lymphocytes.
    Nature. 1975 Feb 20;253(5493):656 PMID: 1089902
  18. Structure and function of immunoglobulin domains. V. Binding, University of immunoglobulin G and fragments to placental membrane preparations.
    J Immunol. 1976 Sep;117(3):882-8 PMID: 956658
  19. Immunoglobulin binding by mouse intestinal epithelial cell receptors.
    J Immunol. 1976 Aug;117(2):587-93 PMID: 950463
  20. Localization of the IgG effector site for monocyte receptors.
    Proc Natl Acad Sci U S A. 1975 Jun;72(6):2081-3 PMID: 1056014
  21. Investigation of the binding site of mouse IgG subclasses to homologous peritoneal macrophages.
    Immunology. 1975 Dec;29(6):1111-8 PMID: 1193685
  22. Binding of monomeric immunoglobulins to Fc receptors of mouse macrophages.
    J Exp Med. 1975 Dec 1;142(6):1520-33 PMID: 1194857
  23. The immune response in the hamster. VII. Studies on cytophilic immunoglobulin.
    J Immunol. 1975 Sep;115(3):693-700 PMID: 1151073
  24. The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments.
    J Exp Med. 1970 Dec 1;132(6):1207-15 PMID: 5511570
  25. Chemical properties of guinea-pig immunoglobulins gamma-1 G, gamma-2 G and gamma M.
    Biochem J. 1970 Dec;120(4):787-95 PMID: 5495151
  26. Conformation changes and dissociation of Fc fragments of rabbit immunoglobulin G as a function of pH.
    Biochem J. 1969 Apr;112(3):357-65 PMID: 5801306
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1978-07-00
Pages
115-23
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1457241
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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