Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.

Infection and immunity ·Vol. 39 ·No. 2 ·1983-02-00 ·Pages 993-9

Szu SC, Clarke S, Robbins JB

Abstract

Some anti-phosphocholine antibodies protect mice against challenge with certain, but not all, pneumococcal types. We found that both their isotype and reactivity with the cell wall C-polysaccharide of encapsulated pneumococci, as measured by immunodiffusion, were important in predicting the protective activity of anti-phosphocholine antibodies. We propose that the specificity of the protective antibodies includes the backbone of the phosphocholine-containing structure.

MeSH Terms

Amino Acid Sequence Animals Antibodies, Monoclonal/immunology Antibody Specificity Chemical Phenomena Chemistry Choline/analogs & derivatives Female Mice Mice, Inbred BALB C Phosphorylcholine/immunology Pneumococcal Infections/immunology Polysaccharides, Bacterial Streptococcus pneumoniae/classification,immunology

Chemicals

Antibodies, Monoclonal Polysaccharides, Bacterial Phosphorylcholine Choline

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Szu S C

Clarke S

Robbins J B

References (32)

32 references, click to expand

IMMUNIZATION OF EXPERIMENTAL ANIMALS WITH A SOLUBLE ANTIGEN EXTRACTED FROM PNEUMOCOCCI.
J Exp Med. 1938 Apr 30;67(5):799-808 PMID: 19870756
The interaction of homogeneous, murine myeloma immunoglobulins with polysaccharide antigens.
Adv Carbohydr Chem Biochem. 1975;31:313-46 PMID: 5861
Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate.
Biochem J. 1968 Dec;110(3):573-82 PMID: 4387389
Protection against group B meningococcal disease. I. Comparison of group-specific and type-specific protection in the chick embryo model.
J Exp Med. 1976 Aug 1;144(2):319-29 PMID: 822114
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
Infect Immun. 1982 Apr;36(1):184-8 PMID: 7076292
Clonotypes of anti-phosphocholine antibodies induced with Proteus morganii (Potter). II. Heterogeneity, class, and idiotypic analyses of the repertoires in BALB/c and A/HeJ mice.
J Immunol. 1982 Feb;128(2):600-7 PMID: 7054290
Binding studies with antibodies having phosphorylcholine specificity and fragments derived from their homologous Streptococcus pneumoniae type 27 capsular polysaccharide.
J Immunol. 1979 Jun;122(6):2356-62 PMID: 87460
Capsulation of pneumococcus with soluble cell wall-like polysaccharide. II. Nonidentity of cell wall and soluble cell wall-like polysaccharides derived from the same and from different pneumococcal strains.
J Exp Med. 1971 Sep 1;134(3 Pt 1):600-17 PMID: 15776564
ACTIVE AND PASSIVE IMMUNITY TO PNEUMOCOCCUS INFECTION INDUCED IN RABBITS BY IMMUNIZATION WITH R PNEUMOCOCCI.
J Exp Med. 1928 Nov 30;48(6):791-804 PMID: 19869521
Specificity for phosphorylcholine of six murine myeloma proteins reactive with Pneumococcus C polysaccharide and beta-lipoprotein.
Biochemistry. 1971 Apr 13;10(8):1424-9 PMID: 4103271
Mouse Igg3 antibodies are highly protective against infection with Streptococcus pneumoniae.
Nature. 1981 Nov 5;294(5836):88-90 PMID: 6170000
The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors.
J Exp Med. 1969 Jun 1;129(6):1275-90 PMID: 4181833
The structure of C-polysaccharide from the walls of Streptococcus pneumoniae.
Biochem J. 1978 Dec 1;175(3):1033-42 PMID: 33662
Comparative studies on the binding properties of human and rabbit C-reactive proteins.
J Immunol. 1980 Mar;124(3):1396-402 PMID: 6766973
PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES.
J Exp Med. 1945 Nov 30;82(6):445-65 PMID: 19871511
Activation of the alternative complement pathway by pneumococcal cell wall teichoic acid.
J Immunol. 1978 Jan;120(1):174-8 PMID: 24071
SPECIFIC PRECIPITATION AND MOUSE PROTECTION IN TYPE I ANTIPNEUMOCOCCUS SERA.
J Exp Med. 1930 Sep 30;52(4):477-83 PMID: 19869781
Structure of the complex polysaccharide C-substance from Streptococcus pneumoniae type 1.
Biochemistry. 1980 Sep 30;19(20):4712-9 PMID: 7426624
Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates.
J Exp Med. 1980 Aug 1;152(2):361-76 PMID: 6967514
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.
Nature. 1981 May 7;291(5810):29-34 PMID: 7231520
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.
J Exp Med. 1970 Aug 1;132(2):211-50 PMID: 5508247
THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : I. THE QUANTITATIVE ASPECTS OF THE MOUSE PROTECTION TEST.
J Exp Med. 1935 Aug 31;62(3):359-74 PMID: 19870421
THE IMMUNOLOGICAL PROPERTIES OF THE HETEROPHILE ANTIGEN AND SOMATIC POLYSACCHARIDE OF PNEUMOCOCCUS.
J Exp Med. 1943 May 1;77(5):435-49 PMID: 19871295
Structural and immunological studies on the pneumococcal C polysaccharide.
J Biol Chem. 1967 Feb 10;242(3):463-70 PMID: 4381522
Antigen-binding myeloma proteins of mice.
Adv Immunol. 1977;25:141-211 PMID: 76433
Immunological properties of anti-pneumococcus rabbit serum as heterophile antibodies.
Jpn J Exp Med. 1968 Feb;38(1):1-10 PMID: 4387140
C-reactive protein is protective against Streptococcus pneumoniae infection in mice.
J Exp Med. 1981 Nov 1;154(5):1703-8 PMID: 7299351
Nature of the cross-protective antigen in subcellular vaccines of Streptococcus pneumoniae.
Infect Immun. 1981 Jan;31(1):160-8 PMID: 7216442
STUDIES ON IMMUNITY TO PNEUMOCOCCUS MUCOSUS (TYPE III) : III. INCREASED RESISTANCE TO TYPE III INFECTION INDUCED IN RABBITS BY IMMUNIZATION WITH R AND S FORMS OF PNEUMOCOCCUS.
J Exp Med. 1927 Jul 31;46(2):343-56 PMID: 19869342
Evaluation of the role of the pneumococcal Forssman antigen (F-polysaccharide) in the cross-serotype protection induced by pneumococcal subcellular preparations.
Infect Immun. 1981 Jan;31(1):169-73 PMID: 7216443
IMMUNOLOGICAL REACTIONS OF THE ISOLATED CARBOHYDRATE AND PROTEIN OF PNEUMOCOCCUS.
J Exp Med. 1925 Aug 31;42(3):347-53 PMID: 19869057
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.
J Exp Med. 1981 Mar 1;153(3):694-705 PMID: 7252411

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.39.2.993-999.1983

Published

1983-02-00

Pages

993-9

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC348048

Subset

External Links

PubMed source DOI: 10.1128/iai.39.2.993-999.1983 PMC Full Text View journal details

Analysis Services

Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.

Contact

WeChat Official Account