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PMID: 7252411 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

The Journal of experimental medicine ·Vol. 153 ·No. 3 ·1981-03-01 ·Pages 694-705

Briles DE, Nahm M, Schroer K, Davie J, Baker P, Kearney J, Barletta R

Abstract

The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.

MeSH Terms
Animals Antibodies Antibody Formation Antibody Specificity Choline/analogs & derivatives Crosses, Genetic Female Hybrid Cells/immunology Injections, Intravenous Male Mice Mice, Inbred BALB C Mice, Inbred CBA Mice, Inbred DBA Phosphorylcholine/immunology Pneumococcal Infections/immunology Streptococcus pneumoniae/immunology
Chemicals
Antibodies Phosphorylcholine Choline
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Briles D E
Nahm M
Schroer K
Davie J
Baker P
Kearney J
Barletta R
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50 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.153.3.694
Published
1981-03-01
Pages
694-705
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186108
Subset
IM
Grants
NIAID NIH HHS · AI-00338 · United States
NIAID NIH HHS · AI-14782 · United States
NIAID NIH HHS · AI-15986 · United States
External Links
PubMed source DOI: 10.1084/jem.153.3.694 PMC Full Text View journal details
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