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PMID: 6929506 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Progesterone induces a rapid increase in [Ca2+]in of Xenopus laevis oocytes.

Wasserman WJ, Pinto LH, O'Connor CM, Smith LD

Abstract

Progesterone causes a rapid increase in the intracellular free calcium level in fully grown amphibian oocytes. When albino Xenopus laevis oocytes were microinjected with the Ca-specific photoprotein aequorin, the calcium-induced luminescence from this protein increased at 40-60 sec after the addition of progesterone and returned to the control level within 5-6 min. No further change in the aequorin glow could be detected through the remainder of the maturation period. This transient increase in cytoplasmic free calcium may be involved in controlling the resumption of oocyte maturation.

MeSH Terms
Aequorin/metabolism Animals Calcium/metabolism Female Kinetics Meiosis/drug effects Oocytes/drug effects,metabolism Ovum/drug effects Progesterone/pharmacology Xenopus
Chemicals
Progesterone Aequorin Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wasserman W J
Pinto L H
O'Connor C M
Smith L D
References (16)
16 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1980-03-00
Pages
1534-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348530
Subset
IM
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