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PMID: 7024128 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Phagocytosis and killing of salmonella typhimurium by peritoneal exudate cells.

Infection and immunity ·Vol. 33 ·No. 2 ·1981-08-00 ·Pages 380-8

Briles DE, Lehmeyer J, Forman C

Abstract

Normal peritoneal cells from conventional, germfree, or nu/nu mice readily killed opsonized salmonellae, an observation that suggests that this activity in the normal peritoneal cavity may not be dependent on either environmental antigenic stimulation or T-cell mediation. In contrast, peritoneal cells elicited 4 days after injection with thioglycolate medium failed to kill opsonized salmonellae but appeared to be highly phagocytic. Peritoneal cells from thioglycolate-treated mice could be induced to kill opsonized salmonellae by giving the mice a primary footpad injection and a secondary intraperitoneal injection of Corynebacterium parvum. This activation by C. parvum appeared to be thymus dependent, since it did not occur in nu/nu mice.

MeSH Terms
Animals Antigens, Bacterial Ascitic Fluid/cytology Female Kinetics Macrophages/immunology Mice Mice, Inbred CBA Mice, Nude Opsonin Proteins Phagocytosis Propionibacterium acnes Salmonella typhimurium/immunology T-Lymphocytes/immunology Thioglycolates/pharmacology
Chemicals
Antigens, Bacterial Opsonin Proteins Thioglycolates
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Briles D E
Lehmeyer J
Forman C
References (34)
34 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.33.2.380-388.1981
Published
1981-08-00
Pages
380-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC350709
Subset
IM
Grants
NIAID NIH HHS · AI 15986 · United States
NCI NIH HHS · CA 13148 · United States
NCI NIH HHS · CA 16673 · United States
External Links
PubMed source DOI: 10.1128/iai.33.2.380-388.1981 PMC Full Text View journal details
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