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PMID: 7040977 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Immunity in cryptococcosis: an overview.

Mycopathologia ·Vol. 77 ·No. 3 ·1982-03-19 ·Pages 183-90

Fromtling RA, Shadomy HJ

Abstract

Cryptococcosis is an often fatal opportunistic fungal infection. Despite efforts to elucidate the role of immunity in host defense against the disease, much remains to be learned. The purpose of this brief review is to provide the reader with an overview of the history of research concerned with host immunity in cryptococcosis. both humoral and cell-mediated studies are included. An effort has been made to present the reader with a comprehensive list of references in the hope of encouraging additional reading and research in this important area.

MeSH Terms
Animals Antibodies, Fungal/biosynthesis,immunology Antigens, Fungal/immunology Blood Physiological Phenomena Cryptococcosis/immunology Cryptococcus/immunology Cryptococcus neoformans/immunology Humans Hypersensitivity, Delayed Immune Tolerance Immunity, Cellular Immunocompetence Macrophage Activation Macrophages/microbiology Phagocytosis Polysaccharides/immunology Vaccines/immunology
Chemicals
Antibodies, Fungal Antigens, Fungal Polysaccharides Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fromtling R A
Shadomy H J
References (81)
81 references, click to expand
  1. Intracellular fate of Cryptococcus neoformans.
    Infect Immun. 1972 Aug;6(2):162-7 PMID: 4569916
  2. Immunological unresponsiveness induced by cryptococcal capsular polysaccharide assayed by the hemolytic plaque technique.
    Infect Immun. 1972 Jun;5(6):896-901 PMID: 4564405
  3. Active immunization against Cryptococcus neoformans.
    J Infect Dis. 1958 May-Jun;102(3):219-26 PMID: 13549767
  4. Formation of histiocyte rings in response to Cryptococcus neoformans infection.
    J Reticuloendothel Soc. 1965 Sep;2(3):249-55 PMID: 5865239
  5. Specific and non-specific immunity in experimental cryptococcosis in mice.
    J Exp Med. 1960 May 1;111:643-65 PMID: 13763700
  6. A study of white blood cell and antibody response in mice infected subcutaneously with Cryptococcus neoformans.
    Sabouraudia. 1965 Jun;4(2):106-11 PMID: 5334780
  7. Effects of stimulation and suppression of cell-mediated immunity on experimental cryptococcosis.
    Infect Immun. 1977 Jul;17(1):187-94 PMID: 885613
  8. Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.
    Infect Immun. 1971 Feb;3(2):287-94 PMID: 16557967
  9. Cryptococcus neoformans. II. Phagocytosis by human leukocytes.
    J Bacteriol. 1967 Nov;94(5):1480-3 PMID: 4862192
  10. Airborne Cryptococcus neoformans: particles from pigeon excreta compatible with alveolar deposition.
    J Infect Dis. 1972 Apr;125(4):412-5 PMID: 4553084
  11. Studies of the capsular substance of Torula histolytica and the immunologic properties of Torula cells.
    J Immunol. 1947 Dec;57(4):395-401 PMID: 20272347
  12. Immunological studies of the anticryptococcal factor of normal human serum.
    Mycopathologia. 1975 Jun 14;55(3):175-8 PMID: 807846
  13. FURTHER STUDIES ON IMMUNITY IN EXPERIMENTAL CRYPTOCOCCOSIS.
    J Exp Med. 1963 Feb 28;117(3):509-20 PMID: 19867226
  14. Decreased virulence in stable, acapsular mutants of cryptococcus neoformans.
    Mycopathologia. 1982 Jul 23;79(1):23-9 PMID: 6750405
  15. Delayed-type hypersensitivity responses in infected mice elicited by cytoplasmic fractions of Cryptococcus neoformans.
    Infect Immun. 1978 Oct;22(1):72-9 PMID: 365751
  16. CRYPTOCOCCUS NEOFORMANS POLYSACCHARIDE: STUDIES OF SEROLOGIC PROPERTIES AND ROLE IN INFECTION.
    J Immunol. 1965 Jun;94:916-20 PMID: 14321434
  17. CHARACTERIZATION OF THE GROWTH INHIBITION FACTOR FOR CRYPTOCOCCUS NEOFORMANS (GIFC) IN HUMAN SERUM.
    Am J Med Sci. 1963 Jul;246:53-7 PMID: 14046016
  18. Opsonization of Cryptococcus neoformans by human immunoglobulin G: role of immunoglobulin G in phagocytosis by macrophages.
    Infect Immun. 1979 Jul;25(1):255-61 PMID: 383614
  19. Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro.
    J Infect Dis. 1972 Apr;125(4):367-76 PMID: 4553080
  20. Passively-acquired immunity in experimental cryptococcosis.
    Sabouraudia. 1965 Jun;4(2):80-4 PMID: 4163434
  21. Growth of Cryptococcus neoformans within human macrophages in vitro.
    Infect Immun. 1973 Feb;7(2):231-6 PMID: 4697791
  22. The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection.
    J Immunol. 1974 Jun;112(6):2260-70 PMID: 4596700
  23. Experimental murine cryptococcosis: effect of hyperimmunization to capsular polysaccharide.
    J Immunol. 1967 May;98(5):914-22 PMID: 5337670
  24. Cryptococcus neoformans IV. The Not-So-Encapsulated Yeast.
    Infect Immun. 1970 Jun;1(6):526-31 PMID: 16557771
  25. Cell-mediated immunity in Cryptococcosis.
    Cell Immunol. 1974 Oct;14(1):12-21 PMID: 4619352
  26. Vaccine and Mycostatin in treatment of cryptococcosis of the respiratory tract.
    Sabouraudia. 1976 Jul;14(2):171-9 PMID: 785628
  27. Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice.
    Infect Immun. 1980 Oct;30(1):5-11 PMID: 7002791
  28. In vitro phagocytosis and intracellular fate of variously encapsulated strains of Cryptococcus neoformans.
    Infect Immun. 1972 Apr;5(4):491-8 PMID: 4564677
  29. A comparison of the immunogenicity of weakly encapsulated and of strongly encapsulated strains of Cryptococcus neoformans (Torula histolytica).
    J Bacteriol. 1950 Feb;59(2):263-75 PMID: 15421955
  30. Experience with a new skin test antigen prepared from Cryptococcus neoformans.
    Am Rev Respir Dis. 1968 Apr;97(4):637-43 PMID: 5644326
  31. Cryptococcal interstitial pneumonia: value of antigen determination.
    N Engl J Med. 1977 Dec 29;297(26):1440-1 PMID: 337142
  32. Cryptococcal culture filtrate antigen for detection of delayed-type hypersensitivity in cryptococcosis.
    Infect Immun. 1979 Jul;25(1):284-92 PMID: 383616
  33. Immune response to Cryptococcus neoformans soluble polysaccharide: immunological unresponsiveness.
    Infect Immun. 1977 Dec;18(3):701-7 PMID: 338489
  34. An antigen for detection of hypersensitivity to Cryptococcus neoformans.
    Proc Soc Exp Biol Med. 1961 Nov;108:498-501 PMID: 14496512
  35. Immunofluorescence studies of reactions at the Cryptococcal capsule.
    J Infect Dis. 1968 Apr;118(2):215-29 PMID: 4870973
  36. Host defense in Cryptococcosis. III. In vivo alteration of immunity.
    Mycopathologia. 1979 Dec 28;69(3):171-8 PMID: 316873
  37. Further studies on acquired resistance to murine cryptococcosis: enhancing effect of Bordetella pertussis.
    J Immunol. 1966 Mar;96(3):525-9 PMID: 4286684
  38. Disseminated cryptococcosis in man: decreased lymphocyte transformation in response to Cryptococcus neoformans.
    J Infect Dis. 1973 Jun;127(6):694-7 PMID: 4575001
  39. Induction of humoral antibody response by soluble polysaccharide of Cryptococcus neoformans.
    Mycopathol Mycol Appl. 1974 Oct 15;54(1):21-30 PMID: 4139653
  40. Opsonization of Cryptococcus neoformans by human immunoglobulin G: masking of immunoglobulin G by cryptococcal polysaccharide.
    Infect Immun. 1979 Jul;25(1):262-7 PMID: 383615
  41. Protein conjugates of polysaccharide from Cryptococcus neoforman s.
    J Immunol. 1967 May;98(5):901-13 PMID: 4164846
  42. Serologic tests in diagnosis and prognosis of cryptococcosis.
    JAMA. 1966 Sep 19;197(12):961-7 PMID: 5953212
  43. Complement depletion in cryptococcal sepsis.
    J Immunol. 1978 May;120(5):1686-90 PMID: 351055
  44. Cryptococcosis histologically resembling histoplasmosis. A light and electron microscopical study.
    Arch Pathol. 1975 Jul;99(7):347-52 PMID: 1096863
  45. Genetic control of susceptibility to Cryptococcus neoformans in mice.
    Infect Immun. 1980 Aug;29(2):494-9 PMID: 7216421
  46. Passive immunization against Cryptococcus neoformans.
    Proc Soc Exp Biol Med. 1958 Jul;98(3):611-4 PMID: 13567788
  47. Cryptococcus neoformans. 3. Inhibition of phagocytosis.
    J Bacteriol. 1968 Jan;95(1):5-8 PMID: 4866104
  48. A statistical survey of deep mycoses in Japan, with particular reference to autopsy cases of cryptococcosis.
    Acta Pathol Jpn. 1974 Sep;24(5):595-609 PMID: 4440497
  49. Resistance against Cryptococcus conferred by intracellular bacteria and protozoa.
    J Infect Dis. 1971 Jan;123(1):22-31 PMID: 5543220
  50. Fluorescent antibody techniques applied to the study of human cryptococcosis.
    JAMA. 1961 Dec 2;178:921-3 PMID: 13926438
  51. DETECTION OF CRYPTOCOCCUS NEOFORMANS ANTIGEN IN BODY FLUIDS BY LATEX PARTICLE AGGLUTINATION.
    Proc Soc Exp Biol Med. 1963 Oct;114:64-7 PMID: 14076914
  52. The interaction of phagocytes and the large-sized parasite Cryptococcus neoformans: cytochemical and ultrastructural study.
    Cell Tissue Res. 1974;152(2):165-74 PMID: 4611641
  53. Skin testing of guinea pigs and footpad testing of mice with a new antigen for detecting delayed hypersensitivity to Cryptococcus neoformans.
    Infect Immun. 1974 Feb;9(2):404-9 PMID: 4593343
  54. Cryptococcal capsular polysaccharide clearance in nonimmune mice.
    Mycopathologia. 1982 Apr 23;78(1):41-5 PMID: 7048100
  55. Response of congenitally athymic (nude) and phenotypically normal mice to Cryptococcus neoformans infection.
    Infect Immun. 1979 Mar;23(3):644-51 PMID: 313367
  56. Immunization of mice with an avirulent pseudohyphal form of Cryptococcus neoformans.
    Mycopathologia. 1979 Sep 28;68(3):179-81 PMID: 394001
  57. Opsonization of encapsulated Cryptococcus neoformans by specific anticapsular antibody.
    Infect Immun. 1981 Mar;31(3):978-84 PMID: 7014468
  58. Humoral defense mechanisms in cryptococcosis: substances in normal human serum, saliva, and cerebrospinal fluid affecting the growth of Cryptococcus neoformans.
    J Infect Dis. 1966 Feb;116(1):75-83 PMID: 5908853
  59. Pseudohyphal forms of Cryptococcus neoformans: decreased survival in vivo.
    Mycopathologia. 1981 Jan 30;73(1):57-9 PMID: 7012632
  60. Immune response to Cryptococcus neoformans soluble polysaccharide. I. Serological assay for antigen and antibody.
    Infect Immun. 1972 Jan;5(1):35-41 PMID: 4570986
  61. Host defense in cryptococcosis. I. An in vivo model for evaluating immune response.
    Int Arch Allergy Appl Immunol. 1978;57(2):101-13 PMID: 346496
  62. Immunization of mice with a mutant of Cryptococcus neoformans. Characterization of the mutant, actively acquired resistance to experimental cryptococcosis in mice.
    Dermatologica. 1976;152(1):16-22 PMID: 780165
  63. The role of late complement components and the alternate complement pathway in experimental cryptococcosis.
    Proc Soc Exp Biol Med. 1973 Oct 1;144(1):312-5 PMID: 4129497
  64. Detection of circulating antibody in human cryptococcosis by means of a bentonite flocculation technique.
    Am Rev Respir Dis. 1967 Apr;95(4):631-7 PMID: 6021124
  65. Host defense in cryptococcosis. II. Cryptococcosis in the nude mouse.
    Cell Immunol. 1978 Oct;40(2):263-74 PMID: 363279
  66. Phagocytosis of Cryptococcus neoformans by alveolar macrophages.
    Infect Immun. 1975 Jan;11(1):73-9 PMID: 1090528
  67. EVALUATION OF A SKIN TEST FOR CRYPTOCOCCOSIS.
    Am Rev Respir Dis. 1965 Apr;91:616 PMID: 14263944
  68. Inhibition of phagocytosis by cryptococcal polysaccharide: dissociation of the attachment and ingestion phases of phagocytosis.
    Infect Immun. 1976 Jul;14(1):62-7 PMID: 780279
  69. [Contributions to the strain-specific virulence of Cryptococcus neoformans. Animal experiments with two C. neoformans-strains isolated from bird manure. Preliminary report (author's transl)].
    Zentralbl Bakteriol Orig A. 1975 Jan;230(1):81-5 PMID: 1101575
  70. Role of macrophages in immunity and pathogenesis of experimental cryptococcosis induced by the airborne route--Part II: Phagocytosis and intracellular fate of Cryptococcus neoformans.
    Mykosen. 1977 Nov;20(11):409-12 PMID: 339078
  71. An ultrastructural examination of the interaction between macrophages and Cryptococcus neoformans.
    J Pathol. 1978 Feb;124(2):103-9 PMID: 363987
  72. Pathogenesis, lethality, and immunizing effect of experimental cutaneous cryptococcosis.
    Infect Immun. 1978 May;20(2):446-55 PMID: 352944
  73. Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga.
    Infect Immun. 1978 Apr;20(1):262-6 PMID: 352931
  74. Kinetics of lymphocyte transformation in mice immunized with viable avirulent forms of Cryptococcus neoformans.
    Infect Immun. 1979 May;24(2):449-53 PMID: 378854
  75. Chemotaxigenesis and activation of the alternative complement pathway by encapsulated and non-encapsulated Cryptococcus neoformans.
    Infect Immun. 1979 Nov;26(2):435-40 PMID: 397927
  76. Natural host resistance to infection with Cryptococcus neoformans. V. The influence of cationic tissue proteins upon phagocytosis and on circulating antibody synthesis.
    J Infect Dis. 1966 Dec;116(5):566-72 PMID: 5957263
  77. Abnormalities in cell-mediated immunity in patients with Cryptococcus neoformans infection.
    J Allergy Clin Immunol. 1975 Jun;55(6):430-41 PMID: 1094054
  78. Role of macrophages in immunity and pathogenesis of experimental cryptococcosis induced by the airborne route.--Part I: Pathogenesis and acquired immunity of Cryptococcus neoformans.
    Mykosen. 1977 Oct;20(10):380-8 PMID: 927451
  79. Delayed hypersensitivity to cryptococcin in man.
    Sabouraudia. 1968 Oct;6(4):285-8 PMID: 5726639
  80. Cryptococcus neoformans. I. Nonencapsulated mutants.
    J Bacteriol. 1967 Nov;94(5):1475-9 PMID: 6057803
  81. Histologic response to capsule-deficient Cryptococcus neoformans.
    Arch Pathol. 1973 Dec;96(6):383-7 PMID: 4594090
Article Info
Journal
Mycopathologia
Abbr.
Mycopathologia
ISSN
0301-486X
DOI
10.1007/BF00518804
Published
1982-03-19
Pages
183-90
Language
English
Region
Netherlands
NLM ID
7505689
Subset
IM
Grants
NIAID NIH HHS · AI-07086 · United States
External Links
PubMed source DOI: 10.1007/BF00518804 View journal details
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