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PMID: 7124730 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Heritable fragile sites on human chromosomes. IX. Population cytogenetics and segregation analysis of the BrdU-requiring fragile site at 10q25.

American journal of human genetics ·Vol. 34 ·No. 5 ·1982-09-00 ·Pages 753-6

Sutherland GR

Abstract

The frequencies of the bromodeoxyuridine (BrdU)-requiring fragile site at 10q25 in 1,026 unselected neonates, 901 patients referred for chromosome studies, and 87 institutionalized retardates were not significantly different from each other. The gene frequency was .013, and the population was in Hardy-Weinberg equilibrium. Segregation analysis confirmed that the fragile site followed codominant inheritance. This fragile site and its nonfragile allelomorph can be considered to constitute the first true chromosomal polymorphism to be described in man.

MeSH Terms
Australia Bromodeoxyuridine Chromosome Fragile Sites Chromosome Fragility Chromosomes, Human, 6-12 and X Female Gene Frequency Genetics, Population Heterozygote Humans Infant, Newborn Male Polymorphism, Genetic
Chemicals
Bromodeoxyuridine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sutherland G R
References (5)
5 references, click to expand
  1. Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.
    Am J Hum Genet. 1980 Jul;32(4):542-8 PMID: 7395866
  2. Heritable fragile sites and lymphocyte culture medium containing BrdU.
    Am J Hum Genet. 1980 Jul;32(4):628-9 PMID: 7395874
  3. Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.
    Am J Hum Genet. 1981 Nov;33(6):946-9 PMID: 7325157
  4. Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.
    Am J Hum Genet. 1982 May;34(3):452-8 PMID: 7081222
  5. The genetics of polymorphism in the Lepidoptera.
    Adv Genet. 1953;5:43-87 PMID: 13040132
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1982-09-00
Pages
753-6
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685438
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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