Home LiteratureArticle Details
PMID: 7152519 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Position of chromosomes in the human interphase nucleus. An analysis of nonhomologous chromatid translocations in lymphocyte cultures after Trenimon treatment and from patients with Fanconi's anemia and Bloom's syndrome.

Human genetics ·Vol. 61 ·No. 4 ·1982-00-00 ·Pages 342-56

Hager HD, Schroeder-Kurth TM, Vogel F

Abstract

The problem of localization of chromosomes in relation to each other in the interphase nucleus of human lymphocytes was investigated by analysis of chromatid and chromosome aberrations observed in lymphocyte cultures of three patients with Fanconi's anemia, one patient with Bloom's syndrome, and in Trenimon-treated (Trenimon, Bayer) normal cells. Distribution of open gaps and breaks is highly correlated with chromosome length and distribution of breaks involved in chromatid translocations in Fanconi's anemia and in Trenimon-treated cells. Both correlations are much lower in Bloom's syndrome. In Fanconi's anemia and in normal cells after Trenimon-treatment, the majority of chromatid translocations are between nonhomologous chromosomes, whereas in Bloom's syndrome mainly homologous chromosomes are involved. Statistical localization of chromosomes in relation to each other in the three-dimensional space by multidimensional scaling gives results consistent with the limited amount of independent evidence.

MeSH Terms
Anemia, Aplastic/genetics Bloom Syndrome/genetics Cell Nucleus/ultrastructure Cells, Cultured Chromatids Chromosome Aberrations Chromosomes, Human/ultrastructure Fanconi Anemia/genetics Female Humans Interphase Lymphocytes/ultrastructure Male Translocation, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hager H D
Schroeder-Kurth T M
Vogel F
References (32)
32 references, click to expand
  1. Arrangement of chromosomes in the interphase nucleus of plants.
    Hum Genet. 1980;55(3):281-95 PMID: 7009386
  2. Chromosome breakage and rejoining of sister chromatids in Bloom's syndrome.
    Chromosoma. 1979 Aug;73(3):275-86 PMID: 510071
  3. Spontaneous chromosomal breakage and high incidence of leukemia in inherited disease.
    Blood. 1971 Jan;37(1):96-112 PMID: 5539134
  4. The rationale for an ordered arrangement of chromatin in the interphase nucleus.
    Am J Hum Genet. 1968 Sep;20(5):440-60 PMID: 5701616
  5. Telomere and centromere association tendencies in the human male metaphase complement.
    Hum Genet. 1980;54(1):69-77 PMID: 7390482
  6. Unscheduled DNA synthesis after partial UV irradiation of the cell nucleus. Distribution in interphase and metaphase.
    Exp Cell Res. 1979 Nov;124(1):111-9 PMID: 499376
  7. Chromosome-specific patterns of mitomycin C-induced rearrangements in human lymphocytes.
    Cytogenet Cell Genet. 1980;28(4):240-50 PMID: 7460625
  8. Stability of centromere-center distances in normal human metaphases.
    Cytogenet Cell Genet. 1977;18(2):61-74 PMID: 862432
  9. CYTOLOGICAL EVIDENCE FOR CROSSING-OVER IN VITRO IN HUMAN LYMPHOID CELLS.
    Science. 1964 Apr 17;144(3616):298-301 PMID: 14169717
  10. Arrangement of chromatin in the nucleus.
    Hum Genet. 1980 Feb;53(2):131-43 PMID: 6987157
  11. Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments.
    Hum Genet. 1982;62(3):201-9 PMID: 7169211
  12. Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments.
    Hum Genet. 1982;60(1):46-56 PMID: 7076247
  13. Cytological demonstration of mitotic crossing-over in man.
    Cytogenet Cell Genet. 1976;17(5):254-67 PMID: 1017317
  14. Chromosome distribution studies in XXY karyotypes.
    J Med Genet. 1982 Feb;19(1):57-62 PMID: 7069748
  15. [The distribution of chemically induced achromatic lesions and breaks on the chromatids of human leukocyte chromosomes].
    Chromosoma. 1969;26(4):475-9 PMID: 5820705
  16. The internal order of the interphase nucleus.
    Humangenetik. 1974;25(4):265-97 PMID: 4464236
  17. Sister chromatid exchanges and chromatid interchanges in bloom's syndrome.
    Humangenetik. 1975 Dec 23;30(4):317-23 PMID: 1218861
  18. [Inter- and intrachromosomal distribution of chromatid translocations in human leukocytes after in vitro treatment with trenimon].
    Chromosoma. 1970;32(2):152-61 PMID: 5534924
  19. Banding in human chromosomes treated with trypsin.
    Nat New Biol. 1972 Jan 12;235(54):52-4 PMID: 4109406
  20. CHROMOSOME EXCHANGES IN HUMAN LEUKOCYTES INDUCED BY MITOMYCIN C.
    Genetics. 1965 Feb;51:181-90 PMID: 14292147
  21. Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.
    Humangenetik. 1975 Jul 23;28(3):191-6 PMID: 1150278
  22. Nonmetric multidimensional scaling without disparities and derivatives: a rankcorrelation-orientated approach through L1-approximation.
    Arch Psychol (Frankf). 1976;128(3-4):240-66 PMID: 1028395
  23. An international system for human cytogenetic nomenclature (1978) ISCN (1978). Report of the Standing Commitee on Human Cytogenetic Nomenclature.
    Cytogenet Cell Genet. 1978;21(6):309-409 PMID: 747930
  24. The relationship between sister chromatid exchanges and chromosome aberrations in Bloom's syndrome.
    Cytogenet Cell Genet. 1977;18(1):13-23 PMID: 871313
  25. Bloom's syndrome and Fanconi's anemia: demonstration of two distinctive patterns of chromosome disruption and rearrangement.
    Humangenetik. 1974;25(4):299-306 PMID: 4464237
  26. Arrangement of prematurely condensed chromosomes in cultured cells and lymphocytes of the Indian muntjac.
    Chromosoma. 1981;83(4):541-53 PMID: 7273958
  27. Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome.
    Chromosoma. 1976 Aug 4;57(1):1-11 PMID: 954549
  28. Mitotic chiasmata and other quadriradials in mitomycin C-treated Bloom's syndrome lymphocytes.
    Chromosoma. 1978 Apr 25;66(3):287-97 PMID: 648281
  29. [Combination-frequencies of human leukocyte chromosomes in chemically induced translocations].
    Chromosoma. 1969;27(3):321-6 PMID: 5365541
  30. MICROTECHNIQUE FOR CULTURING LEUKOCYTES FROM WHOLE BLOOD.
    Cytogenetics. 1963;2:57-60 PMID: 14099759
  31. The central localization of the small and early replicating chromosomes in human diploid metaphase figures.
    Hum Genet. 1982;60(3):249-56 PMID: 7106755
  32. Mitotic crossing-over and segregation in man.
    Hum Genet. 1981;59(2):93-100 PMID: 7035337
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00276599
Published
1982-00-00
Pages
342-56
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00276599 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2