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PMID: 7559731 Published · ppublish English Journal Article

HTLV-1 oncoprotein Tax deregulates transcription of cellular genes through multiple mechanisms.

Journal of cancer research and clinical oncology ·Vol. 121 ·No. 9-10 ·1995-00-00 ·Pages 521-8

Yoshida M

Abstract

Infection of a human retrovirus HTLV-1 induces adult T cell leukemia and a neurological disease, HAM/TSP. Regulatory protein Tax of HTLV-1 is thought to contribute to the pathogenesis. We have studied the mechanism of transcriptional activation induced by Tax protein and identified two independent mechanisms: (a) binding to the enhancer-binding proteins, CREB, CREM, NF-kappa B and SRF, resulting in the activation of these factors through indirect binding to each specific DNA sequence, and (b) binding to I kappa B protein resulting in the suppression of the negative regulator I kappa B, which binds to NF-kappa B. In addition to these factors, a new protein GLI/THP is also involved in the transactivation. On the basis of these mechanisms, gene regulations in vitro and in vivo in HTLV-1-infected cells are discussed.

MeSH Terms
Base Sequence Cell Transformation, Viral Cyclic AMP Response Element Modulator Cyclic AMP Response Element-Binding Protein/physiology DNA-Binding Proteins/physiology Enhancer Elements, Genetic Gene Expression Regulation, Viral Gene Products, tax/physiology Human T-lymphotropic virus 1/genetics Humans Kruppel-Like Transcription Factors Molecular Sequence Data NF-kappa B/physiology Nuclear Proteins/physiology Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins c-fos/physiology RNA, Messenger/genetics Repressor Proteins Serum Response Factor Transcription Factor RelB Transcription Factors Transcription, Genetic Transcriptional Activation Zinc Finger Protein Gli2
Chemicals
Cyclic AMP Response Element-Binding Protein DNA-Binding Proteins GLI2 protein, human Gene Products, tax Kruppel-Like Transcription Factors NF-kappa B Nuclear Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-fos RELB protein, human RNA, Messenger Repressor Proteins Serum Response Factor Transcription Factors Zinc Finger Protein Gli2 Cyclic AMP Response Element Modulator Transcription Factor RelB
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Yoshida M
Department of Cellular and Molecular Biology, University of Tokyo, Japan.
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Article Info
Journal
Journal of cancer research and clinical oncology
Abbr.
J Cancer Res Clin Oncol
ISSN
0171-5216
DOI
10.1007/BF01197764
Published
1995-00-00
Pages
521-8
Language
English
Region
Germany
NLM ID
7902060
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01197764 View journal details
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