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PMID: 7561702 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

The Journal of experimental medicine ·Vol. 182 ·No. 4 ·1995-10-01 ·Pages 993-1004

Cardell S, Tangri S, Chan S, Kronenberg M, Benoist C, Mathis D

Abstract

Rather unexpectedly, major histocompatibility complex class II-deficient mice have a significant population of peripheral CD4+ T lymphocytes. We have investigated these cells at the population and clonal levels. CD4+ T lymphocytes from class II-deficient animals are thymically derived, appear early in ontogeny, exhibit the phenotype of resting memory cells, are potentially functional by several criteria, and have a diverse T cell receptor repertoire. They do not include substantially elevated numbers of NK1.1+ cells. Hybridomas derived after polyclonal stimulation of the CD4+ lymphocytes from class II-deficient animals include a subset with an unusual reactivity pattern, responding to splenocytes from many mouse strains including the strain of origin. Most members of this subset recognize the major histocompatibility complex class Ib molecule CD1; their heterogeneous reactivities and T cell receptor usage further suggest the involvement of peptides and/or highly variable posttranslational modifications.

MeSH Terms
Animals Antigens, CD1/immunology Autoimmunity Base Sequence CD4-Positive T-Lymphocytes/immunology Clone Cells Genetic Variation Histocompatibility Antigens Class I Histocompatibility Antigens Class II/genetics,immunology Hybridomas Lymph Nodes/cytology,immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred NOD Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta/genetics Species Specificity Spleen/cytology,immunology Thymus Gland/cytology
Chemicals
Antigens, CD1 Histocompatibility Antigens Class I Histocompatibility Antigens Class II Receptors, Antigen, T-Cell, alpha-beta
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cardell S
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis Pasteur, Illkirch, CU de Strasbourg, France.
Tangri S
Chan S
Kronenberg M
Benoist C
Mathis D
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.182.4.993
Published
1995-10-01
Pages
993-1004
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192275
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.182.4.993 PMC Full Text View journal details
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