Induction of interferon synthesis in mice by fractions from Nocardia.

Infection and immunity ·Vol. 19 ·No. 2 ·1978-02-00 ·Pages 353-6

Barot-Ciorbaru R, Wietzerbin J, Petit JF, Chedid L, Falcoff E, Lederer E

Abstract

Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.

MeSH Terms

Animals Epitopes Female Interferon Inducers Interferons/blood,immunology Mice Mitogens/pharmacology Nocardia Peptidoglycan/pharmacology Solubility Subcellular Fractions Water

Chemicals

Epitopes Interferon Inducers Mitogens Peptidoglycan Water Interferons

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Barot-Ciorbaru R

Wietzerbin J

Petit J F

Chedid L

Falcoff E

Lederer E

References (13)

13 references, click to expand

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Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia.
Proc Natl Acad Sci U S A. 1974 May;71(5):1602-6 PMID: 4525452
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.19.2.353-356.1978

Published

1978-02-00

Pages

353-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414089

Subset

External Links

PubMed source DOI: 10.1128/iai.19.2.353-356.1978 PMC Full Text View journal details

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Induction of interferon synthesis in mice by fractions from Nocardia.

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